当前位置: X-MOL 学术Cell Death Differ. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Regulating GSDMB pore formation: to ignite or inhibit?
Cell Death and Differentiation ( IF 13.7 ) Pub Date : 2023-04-11 , DOI: 10.1038/s41418-023-01163-8
Jianbin Ruan 1
Affiliation  

In the recent Nature, Wang et al. and Zhong et al. present the cryo-EM structures of Gasdermin B (GSDMB) pore and strucures of GSDMB in complex with a Shigella effector, IpaH7.8. The structures shed light on the structural mechanisms that govern GSDMB-mediated pyroptosis, a process that is regulated by pathogenic bacteria and alternative splicing.

中文翻译:


调节 GSDMB 孔隙形成:点燃还是抑制?



在最近的《自然》杂志上,王等人。和钟等人。展示了 Gasdermin B (GSDMB) 孔的冷冻电镜结构以及 GSDMB 与志贺氏菌效应子 IpaH7.8 复合物的结构。这些结构揭示了控制 GSDMB 介导的细胞焦亡的结构机制,这是一个受病原菌和选择性剪接调节的过程。
更新日期:2023-04-12
down
wechat
bug