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A pH and Temperature Dual-Responsive Microgel-Embedded, Adhesive, and Tough Hydrogel for Drug Delivery and Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-04-10 , DOI: 10.1021/acsami.2c21255 Xuwen Peng 1 , Qian Peng 2 , Meng Wu 1 , Wenda Wang 1 , Yongfeng Gao 1, 2 , Xiong Liu 3 , Yongxiang Sun 1 , Diling Yang 1 , Qiongyao Peng 1 , Tao Wang 1 , Xing-Zhen Chen 3 , Jifang Liu 2 , Hao Zhang 1 , Hongbo Zeng 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-04-10 , DOI: 10.1021/acsami.2c21255 Xuwen Peng 1 , Qian Peng 2 , Meng Wu 1 , Wenda Wang 1 , Yongfeng Gao 1, 2 , Xiong Liu 3 , Yongxiang Sun 1 , Diling Yang 1 , Qiongyao Peng 1 , Tao Wang 1 , Xing-Zhen Chen 3 , Jifang Liu 2 , Hao Zhang 1 , Hongbo Zeng 1
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Stimuli-responsive hydrogels have attracted much attention over the past decade for potential bioengineering applications such as wound dressing and drug delivery. In this work, a pH and temperature dual-responsive microgel-embedded hydrogel has been fabricated by incorporating poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAAm-co-AAc) based microgel particles into polyacrylamide (PAAm)/chitosan (CS) semi-interpenetrating polymer network (semi-IPN), denoted as microgel@PAM/CS. The resultant hydrogel possesses excellent mechanical properties including stretchability, compressibility, and elasticity. In addition, the microgel@PAM/CS hydrogels can tightly adhere to the surfaces of a variety of tissues such as porcine skin, kidney, intestine, liver, and heart. Moreover, it shows controlled dual-drug release profile of both bovine serum albumin (BSA) (as a model protein) and sulfamethoxazole (SMZ), an antibiotic. Excellent antimicrobial properties are obtained for SMZ-loaded microgel@PAM/CS hydrogels. Compared with traditional drug administration methods such as by mouth, injection, and inhalation, the microgel@PAM/CS hydrogels possess advantages such as higher drug loading efficiency (by more than 80%) and controllable and sustained (over 48 h) release. The microgel@PAM/CS hydrogels can significantly enhance the wound healing process. This work provides a facile approach for the fabrication of multifunctional stimuli-responsive microparticle-embedded hydrogels with semi-IPN structures, and the as-prepared microgel@PAM/CS hydrogels have great potential for applications as smart wound dressing materials in biomedical engineering.
中文翻译：
用于药物输送和伤口愈合的 pH 和温度双重响应微凝胶嵌入、粘合剂和坚韧的水凝胶
在过去十年中，刺激响应水凝胶因其潜在的生物工程应用（如伤口敷料和药物输送）而备受关注。在这项工作中，通过加入聚（N-异丙基丙烯酰胺-co-丙烯酸）（PNIPAAm- co-AAc）基微凝胶颗粒转化为聚丙烯酰胺（PAAm）/壳聚糖（CS）半互穿聚合物网络（semi-IPN），表示为microgel@PAM/CS。所得水凝胶具有优异的机械性能，包括可拉伸性、可压缩性和弹性。此外，microgel@PAM/CS水凝胶可以紧密粘附在猪皮肤、肾脏、肠道、肝脏和心脏等多种组织的表面。此外，它显示了牛血清白蛋白 (BSA)（作为模型蛋白）和抗生素磺胺甲恶唑 (SMZ) 的受控双药释放曲线。负载 SMZ 的 microgel@PAM/CS 水凝胶获得了优异的抗菌性能。与口服、注射、吸入等传统给药方式相比，microgel@PAM/CS水凝胶具有更高的载药效率（超过80%）和可控且持续（超过48小时）释放等优点。microgel@PAM/CS 水凝胶可以显着促进伤口愈合过程。这项工作为制备具有半 IPN 结构的多功能刺激响应微粒嵌入水凝胶提供了一种简便的方法，所制备的 microgel@PAM/CS 水凝胶在生物医学工程中作为智能伤口敷料材料具有巨大的应用潜力。
更新日期：2023-04-10
中文翻译：
用于药物输送和伤口愈合的 pH 和温度双重响应微凝胶嵌入、粘合剂和坚韧的水凝胶
在过去十年中，刺激响应水凝胶因其潜在的生物工程应用（如伤口敷料和药物输送）而备受关注。在这项工作中，通过加入聚（N-异丙基丙烯酰胺-co-丙烯酸）（PNIPAAm- co-AAc）基微凝胶颗粒转化为聚丙烯酰胺（PAAm）/壳聚糖（CS）半互穿聚合物网络（semi-IPN），表示为microgel@PAM/CS。所得水凝胶具有优异的机械性能，包括可拉伸性、可压缩性和弹性。此外，microgel@PAM/CS水凝胶可以紧密粘附在猪皮肤、肾脏、肠道、肝脏和心脏等多种组织的表面。此外，它显示了牛血清白蛋白 (BSA)（作为模型蛋白）和抗生素磺胺甲恶唑 (SMZ) 的受控双药释放曲线。负载 SMZ 的 microgel@PAM/CS 水凝胶获得了优异的抗菌性能。与口服、注射、吸入等传统给药方式相比，microgel@PAM/CS水凝胶具有更高的载药效率（超过80%）和可控且持续（超过48小时）释放等优点。microgel@PAM/CS 水凝胶可以显着促进伤口愈合过程。这项工作为制备具有半 IPN 结构的多功能刺激响应微粒嵌入水凝胶提供了一种简便的方法，所制备的 microgel@PAM/CS 水凝胶在生物医学工程中作为智能伤口敷料材料具有巨大的应用潜力。
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