Selenium nanoparticles (SeNPs) are a unique type of nano-sized elemental selenium that have recently found wide application in biomedicine. It has been shown that the properties of SeNPs can be varied by different fabrication methods. Moreover, SeNPs have various therapeutic effects in medical applications due to their excellent biological and adaptable physical properties. At the same time, SeNPs can be used as a carrier medium for various therapeutic substances, which can bring out the full curative effects of the drugs. In this review, the differences in bioactivity properties of SeNPs prepared from different substances were reviewed; the therapeutic effects and mechanisms of SeNPs in cancer, inflammation, neurodegenerative diseases, diabetes, reproductive diseases, cardiovascular diseases, and other diseases were discussed; and the importance of the development of SeNPs was further emphasized.

硒纳米粒子 (SeNPs) 是一种独特类型的纳米级元素硒，最近在生物医学中得到广泛应用。已经表明，SeNP 的特性可以通过不同的制造方法而改变。此外，SeNPs由于其优异的生物学和适应性物理特性，在医学应用中具有多种治疗作用。同时，SeNPs可以作为各种治疗物质的载体介质，可以发挥药物的全部疗效。在这篇综述中，生物活性的差异审查了由不同物质制备的 SeNP 的特性；讨论了SeNPs在癌症、炎症、神经退行性疾病、糖尿病、生殖系统疾病、心血管疾病等疾病中的治疗作用和机制；并进一步强调了开发SeNPs的重要性。