Wearable biosensors monitoring various biomarkers in sweat provide comprehensive and prompt profiling of health states at molecular levels. Cytokines existed in sweat with trace amounts play an important role in cellular activity modulation. Unfortunately, flexible and wearable biosensors for cytokine monitoring have not yet been achieved due to the limitation of membrane-based structure and sensing strategy. Herein, we develop a novel electrochemical fabric based on aptamer-functionalized carbon nanotube/graphene fibers for real-time and in situ monitoring of IL-6, a paramount cytokine biomarker for inflammation and cancer. This fabric system possesses flexibility, anti-fatigue ability and breathability for wearable applications and can apply to different body parts in various forms. Moreover, the electrochemical fabric can track other biomarkers by replacing the coupling aptamer, serving as a universal platform for sweat analysis. This fabric-based platform holds the potential to facilitate an intelligent and personalized health monitoring approach.

监测汗液中各种生物标志物的可穿戴生物传感器可在分子水平上提供全面而及时的健康状况分析。汗液中存在的微量细胞因子在细胞活动调节中起着重要作用。不幸的是，由于基于膜的结构和传感策略的限制，尚未实现用于细胞因子监测的柔性和可穿戴生物传感器。在此，我们开发了一种基于适体功能化碳纳米管/石墨烯纤维的新型电化学织物，用于实时和原位监测 IL-6，IL-6 是炎症和癌症的重要细胞因子生物标志物。该织物系统具有可穿戴应用的柔韧性、抗疲劳能力和透气性，可以多种形式应用于不同的身体部位。而且，电化学织物可以通过替换耦合适体来追踪其他生物标志物，作为汗液分析的通用平台。这种基于织物的平台具有促进智能和个性化健康监测方法的潜力。