<br>Tenascin C 的生物学及其在生理学和病理学中的作用。,Current medicinal chemistry

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Tenascin C 的生物学及其在生理学和病理学中的作用。
Current medicinal chemistry Pub Date : 2024-01-01 , DOI: 10.2174/0929867330666230404124229
Malihehsadat Abedsaeidi ₁ , Farzaneh Hojjati ₂ , Amin Tavassoli ₃ , Amirhossein Sahebkar _{4,

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Affiliation

Tenascin-C (TNC) 是一种多模块细胞外基质 (ECM) 蛋白六聚体，具有多种分子形式 (180-250 kDa)，通过前 mRNA 水平的选择性剪接和蛋白质修饰产生。分子系统发育表明TNC的氨基酸序列是脊椎动物中高度保守的蛋白质。 TNC 具有结合伙伴，包括纤连蛋白、胶原蛋白、原纤维蛋白-2、骨膜素、蛋白聚糖和病原体。各种转录因子和细胞内调节因子严格调节 TNC 表达。 TNC 在细胞增殖和迁移中发挥重要作用。与胚胎组织不同，TNC 蛋白分布在成人的少数组织中。然而，在炎症、伤口愈合、癌症和其他病理状况中观察到较高的 TNC 表达。它广泛表达于多种人类恶性肿瘤中，被认为是癌症进展和转移的关键因素。此外，TNC 还能增加促炎和抗炎信号通路。它已被确定为骨骼肌受损、心脏病和肾纤维化等组织损伤的重要因素。这种多模块六聚体糖蛋白可调节先天性和适应性免疫反应，从而调节多种细胞因子的表达。此外，TNC 是一种重要的调节分子，通过多种信号通路影响神经元疾病的发生和进展。我们全面概述了 TNC 的结构和表达特性及其在生理和病理条件下的潜在功能。

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Biology of Tenascin C and its Role in Physiology and Pathology.

Tenascin-C (TNC) is a multimodular extracellular matrix (ECM) protein hexameric with several molecular forms (180-250 kDa) produced by alternative splicing at the pre-mRNA level and protein modifications. The molecular phylogeny indicates that the amino acid sequence of TNC is a well-conserved protein among vertebrates. TNC has binding partners, including fibronectin, collagen, fibrillin-2, periostin, proteoglycans, and pathogens. Various transcription factors and intracellular regulators tightly regulate TNC expression. TNC plays an essential role in cell proliferation and migration. Unlike embryonic tissues, TNC protein is distributed over a few tissues in adults. However, higher TNC expression is observed in inflammation, wound healing, cancer, and other pathological conditions. It is widely expressed in a variety of human malignancies and is recognized as a pivotal factor in cancer progression and metastasis. Moreover, TNC increases both pro-and anti-inflammatory signaling pathways. It has been identified as an essential factor in tissue injuries such as damaged skeletal muscle, heart disease, and kidney fibrosis. This multimodular hexameric glycoprotein modulates both innate and adaptive immune responses regulating the expression of numerous cytokines. Moreover, TNC is an important regulatory molecule that affects the onset and progression of neuronal disorders through many signaling pathways. We provide a comprehensive overview of the structural and expression properties of TNC and its potential functions in physiological and pathological conditions.

更新日期：2023-04-04

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