Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2023-04-06 , DOI: 10.1007/s13659-023-00376-1 Qi-Qi Zhang 1, 2 , Kun Hu 1 , Han-Dong Sun 1 , Pema-Tenzin Puno 1
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Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E–H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM.
Graphical Abstract
中文翻译：
四种新的羊毛烷三萜类化合物具有来自 Kadsura coccinea 茎的扩展 π 共轭系统
四种新的 14(13 → 12)-abeolanostane 三萜类化合物具有扩展的π共轭系统，kadcoccitanes E–H ( 1 – 4 )，是通过使用 HPLC − UV 引导方法从Kadsura coccinea的茎中获得的。它们的结构和构型测定是通过广泛的光谱分析和量子化学计算来完成的。测试了 Kadcoccitanes E–H 对五种人类肿瘤细胞系（HL-60、A-549、SMMC-7721、MDA-MB-231、SW-480）的细胞毒活性，但它们在 40 μM 浓度下均未表现出活性.
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