Aqueous zinc-ion batteries (AZIBs) have become a hotspot for electrochemical energy storage owing to the high safety, low cost, environmental friendliness, and favorable rate performance. However, the serious dissolution of cathode materials in aqueous electrolytes would lead to poor cyclability, which should be addressed before commercialization. Herein, we designed a Ti-doped V₂O₅ with yolk-shell microspherical structure for AZIBs. The Ti doping stabilizes the crystal structure and relieves the dissolution of V₂O₅ in aqueous ZnSO₄ electrolyte. The optimized sample, Ti_0.2V_1.8O_4.9, delivers a high capacity (355 mAh/g at 0.05 A/g) as well as good capacity retention (89% after 2500 cycles at 1.0 A/g). This work provides an effective strategy to mitigate the dissolution of cathode material in aqueous ZnSO₄ electrolyte for cyclability enhancement.