In contrast to the conventional passive reaction to analytes, here, we create a proof-of-concept nanochannel system capable of on-demand recognition of the target to achieve an unbiased response. Inspired by light-activatable biological channelrhodopsin-2, photochromic spiropyran/anodic aluminium oxide nanochannel sensors are constructed to realize a light-controlled inert/active-switchable response to SO₂ by ionic transport behaviour. We find that light can finely regulate the reactivity of the nanochannels for the on-demand detection of SO₂. Pristine spiropyran/anodic aluminium oxide nanochannels are not reactive to SO₂. After ultraviolet irradiation of the nanochannels, spiropyran isomerizes to merocyanine with a carbon‒carbon double bond nucleophilic site, which can react with SO₂ to generate a new hydrophilic adduct. Benefiting from increasing asymmetric wettability, the proposed device exhibits a robust photoactivated detection performance in SO₂ detection in the range from 10 nM to 1 mM achieved by monitoring the rectified current.

与传统的对分析物的被动反应相反，在这里，我们创建了一个概念验证纳米通道系统，能够按需识别目标以实现无偏见的响应。受光激活生物通道视紫红质 2 的启发，构建了光致变色螺吡喃/阳极氧化铝纳米通道传感器，以通过离子传输行为实现对 SO ₂的光控惰性/主动切换响应。我们发现光可以精细调节纳米通道的反应性以按需检测 SO ₂。_{原始螺吡喃/阳极氧化铝纳米通道对 SO 2}没有反应. 纳米通道经紫外线照射后，螺吡喃异构化为带有碳-碳双键亲核位点的部花青，其可与SO ₂反应生成新的亲水加合物。受益于增加的不对称润湿性，所提出的装置在通过监测整流电流实现的 10 nM 至 1 mM 范围内的SO _{2检测中表现出强大的光激活检测性能。}