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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2011-11-12 , DOI: 10.1016/j.bmcl.2011.11.019 Patrick A. Plé , Frédéric Jung , Sue Ashton , Laurent Hennequin , Romuald Laine , Rémy Morgentin , Georges Pasquet , Sian Taylor
中文翻译：
发现对VEGFR-2和PDGFR酪氨酸激酶具有高亲和力的新型喹唑啉醚抑制剂AZD2932
更新日期：2011-11-12
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2011-11-12 , DOI: 10.1016/j.bmcl.2011.11.019 Patrick A. Plé , Frédéric Jung , Sue Ashton , Laurent Hennequin , Romuald Laine , Rémy Morgentin , Georges Pasquet , Sian Taylor
A new series of Quinazoline Ether Inhibitor which potently inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932.
中文翻译：
发现对VEGFR-2和PDGFR酪氨酸激酶具有高亲和力的新型喹唑啉醚抑制剂AZD2932
本文介绍了一系列新的喹唑啉醚抑制剂，该抑制剂可有效抑制VEGFR-2和PDGFR酪氨酸激酶。体外，药代动力学和体内评估导致选择AZD2932。
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