Our study is guided by Beck’s cognitive stress-vulnerability model of depression. We examined the associations between perceived everyday discrimination (PED) and TNF-⍺, an inflammatory biomarker associated with risk for severe illness, through the negative cognitive triad (NCT; negative thoughts about the self, world, and future) and depressive symptoms in adolescents. We utilized a sample of 99 adolescents (36.4% female; ages 13–16, M = 14.10, SD = 0.52) in our cross-sectional study. We used PROCESS and AMOS to compute regressions and direct, indirect, and total effects of PED, NCT aspects and depressive symptoms on TNF-⍺. Negative views of the self and world mediated between PED and depressive symptoms and that negative views of the self and future mediated between PED and TNF-⍺. In conclusion, Beck’s theory can be expanded to physical health providing directions for addressing mental and physical health simultaneously by restructuring adolescents’ negative view of the self.

我们的研究以 Beck 的抑郁症认知压力脆弱性模型为指导。我们通过青少年的负面认知三联征 （NCT;对自我、世界和未来的消极想法）和抑郁症状，检查了感知到的日常歧视 （PED） 与 TNF-⍺（一种与重病风险相关的炎症生物标志物）之间的关联。在我们的横断面研究中，我们使用了 99 名青少年 （36.4% 为女性;年龄 13-16 岁，M = 14.10，SD = 0.52） 的样本。 我们使用 PROCESS 和 AMOS 计算 PED 、 NCT 方面和抑郁症状对 TNF-⍺ 的回归和直接、间接和总影响。在 PED 和抑郁症状之间中介的对自我和世界的消极看法，以及在 PED 和 TNF 之间介导的对自我和未来的消极看法-⍺。总之，贝克的理论可以扩展到身体健康，通过重组青少年对自我的消极看法，为同时解决心理和身体健康问题提供方向。