具有高效炎症细胞因子靶向的类中性粒细胞仿生 AIE 纳米颗粒可实现精确的光热治疗和炎症缓解,ACS Nano

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具有高效炎症细胞因子靶向的类中性粒细胞仿生 AIE 纳米颗粒可实现精确的光热治疗和炎症缓解
ACS Nano ( IF 15.8 ) Pub Date : 2023-04-03 , DOI: 10.1021/acsnano.2c11762
Wentao Wang ₁ , Yumeng Gao ₂ , Ming Zhang ₃ , Yuanyuan Li ₄ , Ben Zhong Tang ₅

Affiliation

尽管光热疗法 (PTT) 通过避免滥用抗生素而作为一种有前途的治疗耐药细菌感染的方法而蓬勃发展，但限制治疗效率的其余挑战是感染病变的靶向特性差和对革兰氏细胞膜的渗透性低- 阴性菌。在此，我们开发了一种仿生中性粒细胞样聚集诱导发射 (AIE) 纳米机器人 (CM@AIE NPs)，用于精确的炎症部位归巢和有效的 PTT 效应。由于其表面负载的中性粒细胞膜，CM@AIE NPs 可以模拟源细胞，从而与免疫调节分子相互作用，否则这些分子会靶向内源性中性粒细胞。再加上AIE发光体（AIEgens）的二次近红外区吸收和优异的光热特性，精确定位，并且可以实现对炎症部位的治疗，从而最大限度地减少对周围正常组织的损害。此外，CM@AIE NP 介导的 PTT 被刺激在体内通过 980 nm 激光照射，这有助于扩大治疗深度并限制对皮肤组织的损害。良好的生物相容性和优异的体内外抗菌效果证明CM@AIE NPs可以为广谱抗菌应用提供策略。

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Neutrophil-like Biomimic AIE Nanoparticles with High-Efficiency Inflammatory Cytokine Targeting Enable Precise Photothermal Therapy and Alleviation of Inflammation

Although photothermal therapy (PTT) has thrived as a promising treatment for drug-resistant bacterial infections by avoiding the abuse of antibiotics, the remaining challenges that limit the treatment efficiency are the poor targeting properties of infected lesions and low penetration to the cell membrane of Gram-negative bacteria. Herein, we developed a biomimetic neutrophil-like aggregation-induced emission (AIE) nanorobot (CM@AIE NPs) for precise inflammatory site homing and efficient PTT effects. Due to their surface-loaded neutrophil membranes, CM@AIE NPs can mimic the source cell and thus interact with immunomodulatory molecules that would otherwise target endogenous neutrophils. Coupled with the secondary near-infrared region absorption and excellent photothermal properties of AIE luminogens (AIEgens), precise localization, and treatment in inflammatory sites can be achieved, thereby minimizing damage to surrounding normal tissues. Moreover, CM@AIE NP-mediated PTT was stimulated in vivo by a 980 nm laser irradiation, which contributed to the extent of the therapeutic depth and limited the damage to skin tissues. The good biocompatibility and excellent in vitro and in vivo antibacterial effects prove that CM@AIE NPs can provide a strategy for broad-spectrum antibacterial applications.

更新日期：2023-04-03

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