Phenolic compounds are known to have a significant effect on human defense system due to their anti-inflammatory efficacy. This can slow down the aging process and strengthen the human immune system. With the growing interest in green chemistry concept, extraction of phenolic compounds from plants has been geared towards a sustainable path with the use of green and environmentally friendly solvents such as natural deep eutectic solvents (NADES). This review discusses both the conventional extraction and the advanced extraction methods of phenolic compounds using NADES with focus on microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE) techniques ensued by a rationale comparison between them. Employing choline chloride-based natural deep eutectic solvents (NADES) is highlighted as one of the promising strategies in green solvent extraction of phenolic compounds in terms of their biodegradability and extraction mechanism. The review also discusses assistive extraction technologies using NADES for a better understanding of their relationship with extraction efficiency. In addition, the review includes an overview of the challenges of recovering phenolic compounds from NADES after extraction, the potential harmful effects of NADES as well as their future perspective.

中文翻译：

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通过辅助技术和天然低共熔溶剂提取酚类化合物

已知酚类化合物由于其抗炎功效而对人体防御系统具有显着影响。这可以减缓衰老过程并增强人体免疫系统。随着人们对绿色化学概念的兴趣日益浓厚，从植物中提取酚类化合物已转向使用绿色环保溶剂（例如天然低共熔溶剂（NADES））的可持续发展道路。本综述讨论了使用 NADES 提取酚类化合物的常规提取方法和高级提取方法，重点介绍了微波辅助提取 (MAE) 和超声辅助提取 (UAE) 技术，并对它们进行了基本原理比较。就酚类化合物的生物降解性和提取机制而言，使用基于氯化胆碱的天然低共熔溶剂 (NADES) 被认为是酚类化合物绿色溶剂提取中有前途的策略之一。该评论还讨论了使用 NADES 的辅助提取技术，以更好地了解它们与提取效率的关系。此外，该综述还概述了提取后从 NADES 中回收酚类化合物的挑战、NADES 的潜在有害影响及其未来前景。