Manganese-Based Antioxidase-Inspired Biocatalysts with Axial Mn−N5 Sites and 2D d-π-Conjugated Networks for Rescuing Stem Cell Fate,Angewandte Chemie International Edition

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Manganese-Based Antioxidase-Inspired Biocatalysts with Axial Mn−N5 Sites and 2D d-π-Conjugated Networks for Rescuing Stem Cell Fate
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-04-01 , DOI: 10.1002/anie.202302329
Zihe Wu ₁ , Yimin Sun ₂ , Shengdong Mu ₁ , Mingru Bai ₂ , Qian Li ₁ , Tian Ma ₁ , Lang Ma ₃ , Fan Chen ₁ , Xianglin Luo ₁ , Ling Ye _{2,

3} , Chong Cheng _{1,

3}

Affiliation

A manganese-coordinated polyphthalocyanine-based biocatalyst (Mn−PcBC) with axial Mn−N₅ sites and 2D d-π-conjugated networks was synthesized. Owing to the unique chemical and electronic structures, Mn−PcBC displays efficient, multifaceted, and robust ROS-scavenging activity and offers promise as an artificial antioxidase for stem-cell therapeutics and the treatment of other ROS-related diseases.

中文翻译：

具有轴向 Mn−N5 位点和 2D d-π 共轭网络的锰基抗氧化酶生物催化剂可挽救干细胞的命运

_{合成了具有轴向 Mn−N 5}位点和 2D d-π 共轭网络的锰配位聚酞菁基生物催化剂 (Mn−PcBC) 。由于独特的化学和电子结构，Mn−PcBC 表现出高效、多方面和强大的 ROS 清除活性，并为干细胞治疗和其他 ROS 相关疾病的治疗提供了作为人工抗氧化酶的前景。

更新日期：2023-04-01

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