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Solvent-free Microwave-assisted Synthesis of 1-(1,3-diphenyl-1H-pyrazol- 4-yl)-3-(2-hydroxyphenyl) Propane-1,3-dione Using K2CO3 as Green Solid Support
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2023-05-04 , DOI: 10.2174/1570178620666230329104520 Navnath R. Dalvi 1 , Namdeo T. Dhokale 1 , Satish B. Kale 1 , Sadashiv S. Nagre 1 , Shankaraiah G. Konda 1
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2023-05-04 , DOI: 10.2174/1570178620666230329104520 Navnath R. Dalvi 1 , Namdeo T. Dhokale 1 , Satish B. Kale 1 , Sadashiv S. Nagre 1 , Shankaraiah G. Konda 1
Affiliation
We herein present the synthesis of 1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxysubstituted phenyl) propane-1,3-dione using microwave irradiation. Reactions were carried out by employing a solvent-free path using K2CO3 as green solid support. The results were compared with those of the conventional method. This microwave-assisted synthesis avoids hazardous solvents and reduces the number of steps and time, providing increased yields. The synthesized products were characterized by IR, 1H NMR, and mass spectrometry.
中文翻译:
以 K2CO3 为绿色固体载体无溶剂微波辅助合成 1-(1,3-二苯基-1H-吡唑-4-基)-3-(2-羟基苯基)丙烷-1,3-二酮
我们在此提出使用微波辐射合成1-(1,3-二苯基-1H-吡唑-4-基)-3-(2-羟基取代的苯基)丙烷-1,3-二酮。使用 K2CO3 作为绿色固体载体,采用无溶剂路径进行反应。将结果与传统方法的结果进行了比较。这种微波辅助合成避免了有害溶剂,减少了步骤数和时间,从而提高了产量。合成产物通过IR、1H NMR、质谱等进行表征。
更新日期:2023-05-04
中文翻译:
以 K2CO3 为绿色固体载体无溶剂微波辅助合成 1-(1,3-二苯基-1H-吡唑-4-基)-3-(2-羟基苯基)丙烷-1,3-二酮
我们在此提出使用微波辐射合成1-(1,3-二苯基-1H-吡唑-4-基)-3-(2-羟基取代的苯基)丙烷-1,3-二酮。使用 K2CO3 作为绿色固体载体,采用无溶剂路径进行反应。将结果与传统方法的结果进行了比较。这种微波辅助合成避免了有害溶剂,减少了步骤数和时间,从而提高了产量。合成产物通过IR、1H NMR、质谱等进行表征。