A simple and efficient synthesis of a variety of 5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives via an cyclization reaction between 3-arylpropiolaldehydes and 1,2,3,4-tetrahydroisoquinolines (THIQs) is reported. The reaction could be efficiently conducted by simply using trifluoroacetic acid (TFA) as the additive, which offered a variety of biologically existent pyrrolo[2,1-a]isoquinolines core with moderate to good yields.

中文翻译：

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通过 TFA 促进的芳基丙醇醛和 1,2,3,4-四氢异喹啉环化合成 5,6-二氢吡咯并 [2,1-a] 异喹啉

报道了通过3-芳基丙醇醛和 1,2,3,4-四氢异喹啉 (THIQ) 之间的环化反应简单有效地合成多种 5,6-二氢吡咯并 [2,1- a ] 异喹啉衍生物。只需使用三氟乙酸 (TFA) 作为添加剂即可高效地进行反应，提供多种生物存在的吡咯并[2,1- a ] 异喹啉核，收率中等至良好。