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NHC-gold(I)-alkyne complexes induced hepatocellular carcinoma cell death through bioorthogonal activation by palladium complex in living system
Chinese Chemical Letters ( IF 9.4 ) Pub Date : 2023-03-31 , DOI: 10.1016/j.cclet.2023.108413
Yunlong Lu , Yuanhao Liu , Zhenlin Liang , Xiaoyan Ma , Lijuan Liu , Zhenfan Wen , Iogann Tolbatov , Alessandro Marrone , Wukun Liu
中文翻译:
NHC-金(I)-炔复合物通过钯复合物在生命系统中的生物正交激活诱导肝细胞癌细胞死亡
更新日期:2023-03-31
Chinese Chemical Letters ( IF 9.4 ) Pub Date : 2023-03-31 , DOI: 10.1016/j.cclet.2023.108413
Yunlong Lu , Yuanhao Liu , Zhenlin Liang , Xiaoyan Ma , Lijuan Liu , Zhenfan Wen , Iogann Tolbatov , Alessandro Marrone , Wukun Liu
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Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes. In this study, Pd(PPh3)2Cl2 was used as a bioorthogonal catalyst to in situ transform the stable N-heterocyclic carbene (NHC)-gold(I)-alkyne complex 5 to its active species which can effectively inhibit thioredoxin reductase (TrxR) and exhibit significant anticancer bioactivity in hepatocellular carcinoma (HCC).
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
NHC-金(I)-炔复合物通过钯复合物在生命系统中的生物正交激活诱导肝细胞癌细胞死亡
生物正交反应可以在生物环境中发生,而不干扰生化过程。本研究采用Pd(PPh 3 ) 2 Cl 2作为生物正交催化剂,将稳定的N-杂环卡宾(NHC)-金(I)-炔配合物5原位转化为其活性物质,可有效抑制硫氧还蛋白还原酶。 (TrxR) 并在肝细胞癌 (HCC) 中表现出显着的抗癌生物活性。