Osteoarthritis (OA) treatment mainly relies on developing new drugs or nanocarriers, while little attention is paid to building novel remedial mode and improving drug loading efficiency. This work reports an integrated nanosystem that not only realizes visual drug loading and release, but also achieves enhanced lubrication and effective joint inflammation therapy based on fluorinated graphene quantum dots (FGQDs). Oxygen introduction promotes FGQDs outstanding water-stability for months, and layered nano-sized structure further guarantees excellent lubricating properties in biomimetic synovial fluid. The special design of chemistry and structure endows FGQDs robust fluorescence in a wide range of pH conditions. Also, the excitation spectrum of FGQDs well overlaps the absorption spectrum of drugs, which further constructs a new concept of internal filtering system to visually monitor drug loading by naked eyes. More importantly, extraordinary long-term lubrication performance is reported, which is the first experimental demonstration of concentration-dependent mutations of coefficient of friction (COF). Cell incubation experiments indicate that drug-loaded FGQDs have good biocompatibility, tracking property of cellular uptake and drug release, which show efficient anti-inflammation potential for H₂O₂-induced chondrocyte degradation by up-regulated cartilage anabolic genes. This study establishes a promising OA treatment strategy that enables to monitor drug loading and release, to enhance long-time lubricating property, and to show effective anti-inflammatory potential for cartilage protection.

骨关节炎（OA）的治疗主要依靠开发新药或纳米载体，而很少关注构建新的治疗模式和提高载药效率。这项工作报道了一种基于氟化石墨烯量子点（FGQD）的集成纳米系统，不仅实现了可视化药物装载和释放，而且还实现了增强润滑和有效的关节炎症治疗。氧气的引入促进了 FGQD 数月出色的水稳定性，层状纳米结构进一步保证了仿生滑液中优异的润滑性能。特殊的化学和结构设计赋予 FGQD 在广泛的 pH 条件下具有强大的荧光性。此外，FGQD 的激发光谱与药物的吸收光谱很好地重叠，进一步构建了内部过滤系统的新概念，可通过肉眼直观地监测药物装载量。更重要的是，报告了非凡的长期润滑性能，这是摩擦系数（COF）浓度依赖性突变的首次实验证明。细胞培养实验表明，载药FGQDs具有良好的生物相容性、细胞摄取和药物释放的跟踪特性，显示出高效的抗炎潜力。₂ O ₂ -通过上调软骨合成代谢基因诱导软骨细胞降解。这项研究建立了一种有前途的 OA 治疗策略，能够监测药物负载和释放，增强长期润滑性能，并显示出有效的抗炎潜力，以保护软骨。