Design and bioanalytical applications of stochastic DNA walkers,Chemical Communications

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Design and bioanalytical applications of stochastic DNA walkers
Chemical Communications ( IF 4.3 ) Pub Date : 2023-03-31 , DOI: 10.1039/d3cc00965c
Guan A Wang ₁ , Chuipeng Kong ₁ , Feng Li _{1,

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Affiliation

Synthetic DNA walkers that are inspired by the walking behaviors of naturally occurring motor proteins have emerged into an important subfield of DNA nanotechnology. While early DNA walkers were designed to walk on one-dimensional (1D) DNA tracks, the development of DNA origami and DNA functionalized micro-/nanomaterials has enabled diverse 2D and 3D tracks. Random walking becomes possible in such platforms and such stochastic DNA walkers can be engineered with much-improved speed and processivity. The invention and improvement of diverse stochastic DNA walkers have made them ideal amplification platforms for analytical and diagnostic applications. In this feature article, we first review the development of DNA walkers with a historical aspect and then focus on the advances in stochastic DNA walkers. We finally elaborated our research efforts to design varying 3D stochastic DNA walkers for rapid and amplified detection of biologically important nucleic acids and proteins.

中文翻译：

随机 DNA 步行者的设计和生物分析应用

受天然运动蛋白行走行为启发的合成 DNA 助行器已成为 DNA 纳米技术的一个重要子领域。虽然早期的 DNA 助行器被设计为在一维 (1D) DNA 轨道上行走，但 DNA 折纸和 DNA 功能化微/纳米材料的发展已经实现了多样化的 2D 和 3D 轨道。在这样的平台上，随机行走成为可能，并且这种随机 DNA 行走器可以设计成具有大大提高的速度和处理能力。多种随机 DNA 步行者的发明和改进使其成为分析和诊断应用的理想扩增平台。在这篇专题文章中，我们首先从历史的角度回顾了 DNA 步行器的发展，然后重点介绍了随机 DNA 步行器的进展。

更新日期：2023-03-31

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