用于周围神经再生的超声响应复合导电丝导管,Small Structures

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用于周围神经再生的超声响应复合导电丝导管
Small Structures ( IF 13.9 ) Pub Date : 2023-03-29 , DOI: 10.1002/sstr.202300045
Hui Zhang _{1,

2,

3} , Huan Wang ₄ , Baojie Wen ₃ , Ling Lu ₃ , Yuanjin Zhao ₃ , Renjie Chai _{1,

2,

5,

6,

7}

Affiliation

由于周围神经损伤的再生能力有限，因此在临床上修复具有挑战性。在此，提出了一种新型聚（3,4-乙撑二氧噻吩）：聚（4-苯乙烯磺酸）（PEDOT：PSS）复合导电丝导管，具有超声（US）触发主动释放功能，用于周围神经再生。该导管由丝素蛋白反蛋白石管状支架和含有热敏材料（聚（N-异丙基丙烯酰胺）、PNIPAM）、PEDOT:PSS 和神经生长因子 (NGF)。受益于这些功能材料和活性因子的整合，丝素蛋白导管表现出优异的生物相容性、柔韧性、导电性和生物活性。特别是，由于US的热效应和PNIPAM的温度响应性，二次填充水凝胶在US触发时发生体积收缩，从而允许响应性NGF释放。此外，PEDOT:PSS的导电性已被证实可以促进神经元和轴突的生长。通过体内实验，证明了 PEDOT:PSS 和超声触发的 NGF 递送对加速受损神经修复的协同作用。

"点击查看英文标题和摘要"

Ultrasound-Responsive Composited Conductive Silk Conduits for Peripheral Nerve Regeneration

Peripheral nerve injuries are challenging to repair clinically due to their limited regenerative capacity. Herein, a novel poly(3,4-ethylenedioxythiophene):poly(4-styrene sulfonate) (PEDOT:PSS) composited conductive silk conduit with ultrasound (US)-triggered active release for peripheral nerve regeneration is presented. The conduit is composed of silk fibroin inverse opal tubular scaffolds and the secondary hydrogel filler that contains thermosensitive material (poly(N-isopropylacrylamide), PNIPAM), PEDOT:PSS, and nerve growth factor (NGF). Benefiting from the integration of these functional materials and active factors, the silk fibroin conduits show excellent biocompatibility, flexibility, conductivity, and bioactivity. In particular, owing to the thermal effect of US and the temperature responsiveness of PNIPAM, the secondary filling hydrogel undergoes volume shrinkage upon US triggering, allowing the responsive NGF release. Besides, the electrical conductivity of PEDOT:PSS has been affirmed to promote neuron and axon outgrowth. Through in vivo experiments, the synergistic effect of PEDOT:PSS and US-triggered delivery of NGF on accelerating injured nerve repair are demonstrated. These results reveal the practical value of the proposed intelligent conductive silk conduits with US responsiveness for nerve regeneration in preclinical studies.

更新日期：2023-03-29

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