The special properties of fluorine atoms and fluorine-containing groups have led to an increasing number of applications for fluorine-containing organic compounds, which are also extremely widely used in the field of new drug development. Unfortunately, naturally fluorinated organics are rare in nature, so the selective introduction of fluorine atoms or fluorine-containing groups into organic molecules is very important for pharmaceutical/synthetic chemists. N-2,2,2-trifluoroethylisatin ketimines have received the attention of many chemists since they were first developed as fluorine-containing synthons in 2015. This paper reviews the organic synthesis reactions in which trifluoroethyl isatin ketimine has been involved in recent years, focusing on the types of reactions and the stereoselectivity of products, and also provides a prospect of its application in this field.

中文翻译：

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N-2,2,2-三氟乙基化酮亚胺的有机合成研究进展

氟原子和含氟基团的特殊性质导致含氟有机化合物的应用越来越多，在新药开发领域也有着极其广泛的应用。不幸的是，天然含氟有机物在自然界中很少见，因此选择性地将氟原子或含氟基团引入有机分子中对于药物/合成化学家来说非常重要。N-2,2,2-三氟乙基靛红酮亚胺自2015年首次被开发为含氟合成子以来，受到众多化学家的关注。本文综述了近年来三氟乙基靛红酮亚胺参与的有机合成反应，重点关于反应类型和产物的立体选择性，