一体化“4A水凝胶”：通过急救止血、抗菌、抗氧化、血管生成促进感染伤口愈合,Small

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一体化“4A水凝胶”：通过急救止血、抗菌、抗氧化、血管生成促进感染伤口愈合
Small ( IF 13.0 ) Pub Date : 2023-03-28 , DOI: 10.1002/smll.202207437
Shanshan Hu ₁ , Zixin Yang ₁ , Qiming Zhai ₁ , Dize Li ₁ , Xingyu Zhu ₁ , Qingqing He ₁ , Lingjie Li ₁ , Richard D Cannon ₂ , Huanan Wang ₃ , Han Tang ₁ , Ping Ji ₁ , Tao Chen ₁

Affiliation

目前使用的伤口敷料效果不佳。因此，需要开发一种具有快速止血和优异抗菌活性等多种功能的高性能药物，以满足全球对伤口愈合产品不断增长的需求。在这里，受到贻贝的强粘附力和纳米金属生物材料的模拟酶活性的启发，作者开发了一种可注射水凝胶，以克服当前伤口敷料的多重限制。该水凝胶是通过聚乙烯醇（PVA）和3,4-二羟基苯丙氨酸（DOPA）之间的酯化反应，然后在Cu ^{2+之间进行儿茶酚-金属配位来合成的。}和 DOPA 的儿茶酚基团形成 PVA-DOPA-Cu (PDPC) 水凝胶。PDPC水凝胶具有优异的组织粘合、抗氧化、光热、抗菌和止血性能。该水凝胶在不同的创伤条件下都能快速有效地止血，包括致命的肝损伤、高压颈动脉破裂，甚至动物模型中致命的心脏穿透伤。此外，研究表明，PDPC水凝胶通过加速上皮再形成、促进胶原蛋白沉积、调节炎症和促进血管形成来影响高性能伤口修复和组织再生。结果表明，PDPC 水凝胶是多种临床应用中快速出血控制和有效伤口愈合的有前途的候选者。

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An All-in-One “4A Hydrogel”: through First-Aid Hemostatic, Antibacterial, Antioxidant, and Angiogenic to Promoting Infected Wound Healing

Currently used wound dressings are ineffective. Hence, there is a need to develop introduce a high-performance medicament with multiple functions including rapid hemostasis and excellent antibacterial activity to meet the growing worldwide demand for wound healing products. Here, inspired by the strong adhesion of mussels and the enzyme-mimicking activity of nanometallic biomaterials, the authors developed an injectable hydrogel to overcome multiple limitations of current wound dressings. The hydrogel is synthesized via esterification reaction between poly(vinyl alcohol) (PVA) and 3,4-dihydroxyphenylalanine (DOPA), followed by catechol-metal coordination between Cu²⁺ and the catechol groups of DOPA to form a PVA-DOPA-Cu (PDPC) hydrogel. The PDPC hydrogel possesses excellent tissue adhesive, antioxidative, photothermal, antibacterial, and hemostatic properties. The hydrogel rapidly and efficiently stopped bleeding under different traumatic conditions, including otherwise-lethal liver injury, high-pressure carotid artery rupture, and even fatal cardiac penetration injuries in animal models. Furthermore, it is demonstrated that the PDPC hydrogel affected high-performance wound repair and tissue regeneration by accelerating re-epithelialization, promoting collagen deposition, regulating inflammation, and contributing to vascularization. The results show that PDPC hydrogel is a promising candidate for rapid hemorrhage control and efficient wound healing in multiple clinical applications.

更新日期：2023-03-28

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