Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation,Chemistry - A European Journal

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Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-03-27 , DOI: 10.1002/chem.202300649
Luisa Maria Gatzemeier _{1,

2} , Franc Meyer ₃ , Ulf Diederichsen ₁ , Tiago Fleming Outeiro _{2,

4,

5,

6}

Affiliation

The aggregation of alpha-Synuclein, a protein associated with several neurodegenerative diseases, can be altered by mutations and by posttranslational modifications, but the precise effects of these alterations are still elusive. Here, we devised a strategy for the chemical synthesis of the protein combining solid-phase peptide synthesis and native chemical ligation. This enables the synthesis of custom-made protein variants to determine their aggregation behavior.

中文翻译：

通过固相肽合成和天然化学连接化学合成 α-突触核蛋白

α-突触核蛋白（一种与多种神经退行性疾病相关的蛋白质）的聚集可以通过突变和翻译后修饰而改变，但这些改变的确切影响仍然难以捉摸。在这里，我们设计了一种结合固相肽合成和天然化学连接的蛋白质化学合成策略。这使得定制蛋白质变体的合成能够确定它们的聚集行为。

更新日期：2023-03-27

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