Tough, Resorbable Polycaprolactone-Based Bimodal Networks for Vat Polymerization 3D Printing,用于还原聚合 3D 打印的坚韧、可吸收的基于聚己内酯的双峰网络,Advanced Functional Materials

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Tough, Resorbable Polycaprolactone-Based Bimodal Networks for Vat Polymerization 3D Printing,用于还原聚合 3D 打印的坚韧、可吸收的基于聚己内酯的双峰网络
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-03-27 , DOI: 10.1002/adfm.202213797
Kerr DG Samson ₁ , Veronica Hidalgo‐Alvarez ₁ , Tim R Dargaville ₂ , Ferry PW Melchels ₁

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Vat polymerization allows for the accurate and fast fabrication of personalized implants and devices. While the technology advances rapidly and more materials become available, the fabrication of flexible yet tough resorbable materials for biomedical applications remains a challenge. Here, a formulation that can be 3D printed with high accuracy using vat polymerization, yielding materials that are tough, degradable, and non-toxic is presented. This unique combination of properties is obtained by combining a long-chain polycaprolactone macromonomer with a small molecule cross-linker. A wide range of properties is achieved by tuning the ratio of these components. The use of benzyl alcohol as a non-volatile, benign solvent enables fabrication on a low-cost desktop 3D printer, with an exposure time of 8 s per 50-micron layer. The 3D-printed networks are tough and elastic with a tensile strength of 11 MPa at 116% elongation at break. Cells attach and proliferate on the networks with a viability of >91%. The networks are fully degradable to soluble products. This new 3D printable material opens up a range of opportunities in biomedical engineering and personalized medicine.,还原聚合可以准确、快速地制造个性化植入物和设备。尽管技术进步迅速，可用材料越来越多，但制造用于生物医学应用的柔性但坚韧的可吸收材料仍然是一个挑战。这里提出了一种可以使用还原聚合进行高精度 3D 打印的配方，产生坚韧、可降解且无毒的材料。这种独特的性能组合是通过将长链聚己内酯大单体与小分子交联剂相结合而获得的。通过调整这些成分的比例可以获得广泛的性能。使用苯甲醇作为非挥发性良性溶剂，可以在低成本桌面 3D 打印机上进行制造，每 50 微米层的曝光时间为 8 秒。3D 打印网络坚韧而富有弹性，拉伸强度为 11 MPa，断裂伸长率为 116%。细胞在网络上附着和增殖，存活率 >91%。该网络可完全降解为可溶性产品。这种新型 3D 打印材料为生物医学工程和个性化医疗带来了一系列机遇。

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更新日期：2023-03-27

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