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Neutrophil Camouflaged Stealth Nanovehicle for Photothermal-Induced Tumor Immunotherapy by Triggering Pyroptosis
Advanced Science ( IF 14.3 ) Pub Date : 2023-03-26 , DOI: 10.1002/advs.202207456
Xuya Yu 1 , Guozheng Xing 1 , Shupei Sheng 1 , Limin Jin 1 , Yan Zhang 1 , Dunwan Zhu 1 , Lin Mei 1 , Xia Dong 1 , Feng Lv 1
Advanced Science ( IF 14.3 ) Pub Date : 2023-03-26 , DOI: 10.1002/advs.202207456
Xuya Yu 1 , Guozheng Xing 1 , Shupei Sheng 1 , Limin Jin 1 , Yan Zhang 1 , Dunwan Zhu 1 , Lin Mei 1 , Xia Dong 1 , Feng Lv 1
Affiliation
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The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing tumor recurrence and metastasis. Inspired by the stealth strategy, a stealthy nanovehicle based on neutrophil camouflage is developed to achieve precise delivery and tumor immunotherapy by triggering pyroptosis. The nanovehicle comprises anti-CD11b- and IR820-conjugated bovine serum albumin nanoparticles loaded with decitabine. Camouflaged by neutrophils, the nanovehicles achieve efficient tumor delivery by neutrophil hitchhiking owing to the biotropism of neutrophils for tumors. The fluorescent signal molecule, IR820, on the nanovehicle acts as a navigation monitor to track the precise delivery of the nanovehicle. The released decitabine upregulates gasdermin E, and laser irradiation activates caspase-3, thereby resulting in pyroptosis, which improves the system's adaptive immune response. In a triple-negative breast cancer animal model, it regulates the immunosuppressive microenvironment for effective tumor immunotherapy and induces a long-lasting and strong immune memory to prevent lung metastasis.
中文翻译：
中性粒细胞伪装隐形纳米载体通过触发细胞焦亡进行光热诱导的肿瘤免疫治疗
通过精确的药物递送调节肿瘤免疫抑制微环境是预防肿瘤复发和转移的有前途的策略。受隐形策略的启发，开发了一种基于中性粒细胞伪装的隐形纳米载体，通过触发细胞焦亡实现精确递送和肿瘤免疫治疗。该纳米载体包含抗 CD11b 和 IR820 缀合的牛血清白蛋白纳米颗粒，其中载有地西他滨。由于嗜中性粒细胞对肿瘤的生物向性，纳米载体被嗜中性粒细胞伪装，通过嗜中性粒细胞搭便车实现有效的肿瘤递送。纳米载体上的荧光信号分子 IR820 充当导航监视器，以跟踪纳米载体的精确传递。释放的地西他滨上调 gasdermin E，激光照射激活 caspase-3，从而导致细胞焦亡，从而改善系统的适应性免疫反应。在三阴性乳腺癌动物模型中，它调节免疫抑制微环境以进行有效的肿瘤免疫治疗，并诱导持久而强大的免疫记忆以防止肺转移。
更新日期：2023-03-26
中文翻译：
中性粒细胞伪装隐形纳米载体通过触发细胞焦亡进行光热诱导的肿瘤免疫治疗
通过精确的药物递送调节肿瘤免疫抑制微环境是预防肿瘤复发和转移的有前途的策略。受隐形策略的启发，开发了一种基于中性粒细胞伪装的隐形纳米载体，通过触发细胞焦亡实现精确递送和肿瘤免疫治疗。该纳米载体包含抗 CD11b 和 IR820 缀合的牛血清白蛋白纳米颗粒，其中载有地西他滨。由于嗜中性粒细胞对肿瘤的生物向性，纳米载体被嗜中性粒细胞伪装，通过嗜中性粒细胞搭便车实现有效的肿瘤递送。纳米载体上的荧光信号分子 IR820 充当导航监视器，以跟踪纳米载体的精确传递。释放的地西他滨上调 gasdermin E，激光照射激活 caspase-3，从而导致细胞焦亡，从而改善系统的适应性免疫反应。在三阴性乳腺癌动物模型中，它调节免疫抑制微环境以进行有效的肿瘤免疫治疗，并诱导持久而强大的免疫记忆以防止肺转移。
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