To improve the therapeutic effect of tumors, developing well-defined hybrid metal-organic frameworks (MOFs) through MOF-on-MOF growth has attracted much attention. In this work, an in situ growth strategy was reported to assemble doxorubicin (DOX)-encapsulated zeolitic imidazolate frameworks (ZIF-8) on the surface of Zr(IV)-based porphyrinic MOFs. Such an approach offers a high controllability in the thickness of the ZIF-8 layer without any requirement of surface modifications on porphyrinic MOFs. Impressively, the acidic pH-response degradation of ZIF-8 promoted the release of DOX in the acidic tumor microenvironment. Upon light irradiation, porphyrinic MOFs can harvest photons to produce plentiful singlet oxygen, thus leading to amplified chemo/PDT therapeutic efficacy. This work paves the way to utilize the hybrid engineering of MOFs for synergistic cancer therapy.

为了提高肿瘤的治疗效果，通过 MOF-on-MOF 生长开发定义明确的杂化金属有机框架 (MOF) 引起了广泛关注。在这项工作中，报道了一种原位生长策略，可在基于 Zr(IV) 的卟啉 MOF 表面组装多柔比星 (DOX) 封装的沸石咪唑酯骨架 (ZIF-8)。这种方法提供了 ZIF-8 层厚度的高度可控性，而不需要对卟啉 MOF 进行任何表面改性。令人印象深刻的是，ZIF-8 的酸性 pH 响应降解促进了酸性肿瘤微环境中 DOX 的释放。在光照射下，卟啉 MOF 可以收集光子以产生大量的单线态氧，从而导致化疗/PDT 治疗效果增强。