当前位置：
X-MOL 学术
›
Adv. Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment
Advanced Materials ( IF 27.4 ) Pub Date : 2023-03-25 , DOI: 10.1002/adma.202212190 Zexu Lin 1 , Dmitry Kireev 2, 3 , Ning Liu 2 , Shubham Gupta 1 , Jessica LaPiano 4 , Sofian N Obaid 1 , Zhiyuan Chen 1 , Deji Akinwande 2, 3 , Igor R Efimov 1, 5, 6
Advanced Materials ( IF 27.4 ) Pub Date : 2023-03-25 , DOI: 10.1002/adma.202212190 Zexu Lin 1 , Dmitry Kireev 2, 3 , Ning Liu 2 , Shubham Gupta 1 , Jessica LaPiano 4 , Sofian N Obaid 1 , Zhiyuan Chen 1 , Deji Akinwande 2, 3 , Igor R Efimov 1, 5, 6
Affiliation
|
Heart rhythm disorders, known as arrhythmias, cause significant morbidity and are one of the leading causes of mortality. Cardiac arrhythmias are frequently treated by implantable devices, such as pacemakers and defibrillators, or by ablation therapy guided by electroanatomical mapping. Both implantable and ablation therapies require sophisticated biointerfaces for electrophysiological measurements of electrograms and delivery of therapeutic stimulation or ablation energy. In this work, a graphene biointerface for in vivo cardiac electrophysiology is reported for the first time. Leveraging sub-micrometer-thick tissue-conformable graphene arrays, sensing and stimulation of the open mammalian heart are demonstrated both in vitro and in vivo. Furthermore, the graphene biointerface treatment of atrioventricular block (the kind of arrhythmia where the electrical conduction from the atria to the ventricles is interrupted) is demonstrated. The graphene arrays show effective electrochemical properties, namely interface impedance down to 40 Ω cm2 at 1 kHz, charge storage capacity up to 63.7 mC cm−2, and charge injection capacity up to 704 µC cm−2. Transparency of the graphene structures allows for simultaneous optical mapping of cardiac action potentials, calcium transients, and optogenetic stimulation while performing electrical measurements and stimulation. The report presents evidence of the significant potential of graphene biointerfaces for advanced cardiac electrophysiology and arrhythmia therapy.
中文翻译：
用于心律失常诊断和治疗的石墨烯生物界面
心律失常，称为心律失常，会导致严重的发病率，并且是导致死亡的主要原因之一。心律失常通常通过植入式设备（例如起搏器和除颤器）或通过电解剖标测引导的消融治疗来治疗。植入式疗法和消融疗法都需要复杂的生物接口，用于电描记图的电生理学测量和治疗性刺激或消融能量的传递。在这项工作中，首次报道了用于体内心脏电生理学的石墨烯生物界面。利用亚微米厚的组织适形石墨烯阵列，在体外和体内都证明了开放哺乳动物心脏的传感和刺激。此外，演示了房室传导阻滞（从心房到心室的电传导中断的一种心律失常）的石墨烯生物界面治疗。石墨烯阵列显示出有效的电化学特性，即界面阻抗低至 40 Ω cm2在 1 kHz 时，电荷存储容量高达 63.7 mC cm -2，电荷注入容量高达 704 µC cm -2。石墨烯结构的透明度允许在执行电测量和刺激时同时光学映射心脏动作电位、钙瞬变和光遗传学刺激。该报告提供了石墨烯生物界面在先进心脏电生理学和心律失常治疗方面的巨大潜力的证据。
更新日期：2023-03-25
中文翻译：
用于心律失常诊断和治疗的石墨烯生物界面
心律失常，称为心律失常，会导致严重的发病率，并且是导致死亡的主要原因之一。心律失常通常通过植入式设备（例如起搏器和除颤器）或通过电解剖标测引导的消融治疗来治疗。植入式疗法和消融疗法都需要复杂的生物接口，用于电描记图的电生理学测量和治疗性刺激或消融能量的传递。在这项工作中，首次报道了用于体内心脏电生理学的石墨烯生物界面。利用亚微米厚的组织适形石墨烯阵列，在体外和体内都证明了开放哺乳动物心脏的传感和刺激。此外，演示了房室传导阻滞（从心房到心室的电传导中断的一种心律失常）的石墨烯生物界面治疗。石墨烯阵列显示出有效的电化学特性，即界面阻抗低至 40 Ω cm2在 1 kHz 时，电荷存储容量高达 63.7 mC cm -2，电荷注入容量高达 704 µC cm -2。石墨烯结构的透明度允许在执行电测量和刺激时同时光学映射心脏动作电位、钙瞬变和光遗传学刺激。该报告提供了石墨烯生物界面在先进心脏电生理学和心律失常治疗方面的巨大潜力的证据。
京公网安备 11010802027423号