Zinc-Based Tannin-Modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair,Advanced Healthcare Materials

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Zinc-Based Tannin-Modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-03-25 , DOI: 10.1002/adhm.202300303
Yitao Zhao ₁ , Jintao Li ₁ , Lingli Liu ₁ , Yue Wang ₁ , Yan Ju ₁ , Chun Zeng ₁ , Zhihui Lu ₁ , Denghui Xie ₁ , Jinshan Guo ₁

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Treatment of infected bone defects is a major clinical challenge; bioactive materials combining sufficient antimicrobial activity and favorable osteogenic ability are urgently needed. In this study, through a facile one-pot hydrothermal reaction of zinc acetate in the presence of tannic acid (TA), with or without silver nitrate (AgNO₃), is used to synthesize a TA or TA and silver nanoparticles (Ag NPs) bulk-modified zinc oxide (ZnO) (ZnO-TA or ZnO-TA-Ag), which is further composited with zein to fabricate porous microparticulate scaffolds for infected bone defect repair. Bulk TA modification significantly improves the release rate of antibacterial metal ions (Zn²⁺ release rate is >100 times that of ZnO). Fast and long-lasting (>35 d) Zn²⁺ and Ag⁺ release guaranteed sufficient antibacterial capability and excellent osteogenic properties in promoting the osteogenic differentiation of bone marrow mesenchymal stem cells and endogenous citric acid production and mineralization and providing considerable immunomodulatory activity in promoting M2 polarization of macrophages. At the same time, synchronously-released TA could scavenge endogenous reactive oxygen species (ROS) and ROS produced by antibacterial metal ions, effectively balancing antibacterial activity and osteogenesis to sufficiently control infection while protecting the surrounding tissue from damage, thus effectively promoting infected bone defect repair.

中文翻译：

具有平衡抗菌活性和成骨作用的锌基单宁改性复合微粒支架，用于修复感染骨缺损

感染性骨缺损的治疗是一项重大的临床挑战；迫切需要结合足够的抗菌活性和良好的成骨能力的生物活性材料。_{在这项研究中，通过醋酸锌在单宁酸（TA）存在下，有或没有硝酸银（AgNO 3}）的简单一锅水热反应，用于合成TA或TA和银纳米颗粒（Ag NPs）本体改性氧化锌 (ZnO)（ZnO-TA 或 ZnO-TA-Ag），进一步与玉米醇溶蛋白复合，制造用于修复感染骨缺损的多孔微粒支架。本体TA修饰显着提高了抗菌金属离子的释放速率（Zn ²⁺释放速率>100倍于ZnO）。快速而持久（>35天）的Zn ²⁺和Ag ⁺释放保证了足够的抗菌能力和优异的成骨特性，促进骨髓间充质干细胞的成骨分化和内源性柠檬酸的产生和矿化，并在促进骨髓间充质干细胞的成骨分化和内源性柠檬酸的产生和矿化方面提供相当大的免疫调节活性巨噬细胞的 M2 极化。同时，同步释放的TA可以清除内源性活性氧（ROS）和抗菌金属离子产生的ROS，有效平衡抗菌活性和成骨作用，充分控制感染，同时保护周围组织免受损伤，从而有效促进感染性骨缺损维修。

更新日期：2023-03-25

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