Double Cross-Linked Biomimetic Hyaluronic Acid-Based Hydrogels with Thermo-Stimulated Self-Contraction and Tissue Adhesiveness for Accelerating Post-Wound Closure and Wound Healing,Advanced Functional Materials

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Double Cross-Linked Biomimetic Hyaluronic Acid-Based Hydrogels with Thermo-Stimulated Self-Contraction and Tissue Adhesiveness for Accelerating Post-Wound Closure and Wound Healing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-03-25 , DOI: 10.1002/adfm.202300710
Yaodong Zhao ₁ , Bingcheng Yi ₂ , Jilin Hu ₁ , Dongjie Zhang ₁ , Guotai Li ₂ , Yun Lu _{1,

3} , Qihui Zhou _{2,

4,

5}

Affiliation

When skin trauma occurs, rapid achievement of the post-wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a wound dressing for accelerating post-wound-closure and wound healing, a thermo-responsive and tissue-adhesive hydrogel with interpenetrating polymer networks (IPN) is fabricated based on N-dimethylbisacrylamide (NIPAM) and glutaraldehyde (GTA) cross-linked hyaluronic acid (HA). Results not only confirm the thermo-stimulated self-contraction and tissue adhesiveness of the HA-based IPN (PNI-HA), which effectively aids wound closure via mechanical stretch, but also verify the hemocompatibility and cytocompatibility of PNI-HA that tend to accelerate wound healing. In vivo, a mouse model of total skin defect demonstrates that PNI-HA acting as hydrogel sealant significantly achieves the sutureless post-wound-closure at the early stage of wound healing, and then promotes wound healing by reducing inflammatory cells infiltration, promoting angiogenesis as well as reducing collagen deposition. These results indicate that the developed thermo-responsive and tissue-adhesive hydrogel dressing offers a candidate to serve as a tissue sealant for wound healing.

中文翻译：

双交联仿生透明质酸基水凝胶，具有热刺激自收缩和组织粘附性，可加速伤口后闭合和伤口愈合

当发生皮肤外伤时，需要快速实现伤口后闭合，以防止微生物入侵，抑制疤痕形成，促进伤口愈合。为了开发用于加速伤口闭合和伤口愈合的伤口敷料，基于N-二甲基双丙烯酰胺 (NIPAM) 和戊二醛 (GTA) 交联透明质酸 (HA)。结果不仅证实了基于 HA 的 IPN (PNI-HA) 的热刺激自收缩和组织粘附性，通过机械拉伸有效地帮助伤口闭合，而且还证实了 PNI-HA 的血液相容性和细胞相容性倾向于加速伤口愈合。在体内，全皮肤缺损的小鼠模型表明，PNI-HA 作为水凝胶密封剂在伤口愈合早期显着实现无缝合后伤口闭合，然后通过减少炎症细胞浸润促进伤口愈合，促进血管生成作为以及减少胶原蛋白沉积。

更新日期：2023-03-26

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