Universal Fully Integrated Wearable Sensor Arrays for the Multiple Electrolyte and Metabolite Monitoring in Raw Sweat, Saliva, or Urine,Analytical Chemistry

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Universal Fully Integrated Wearable Sensor Arrays for the Multiple Electrolyte and Metabolite Monitoring in Raw Sweat, Saliva, or Urine
Analytical Chemistry ( IF 6.7 ) Pub Date : 2023-03-24 , DOI: 10.1021/acs.analchem.3c00361
Yanni Bi ₁ , Mimi Sun ₁ , Jingjuan Wang ₁ , Ziyu Zhu ₁ , Jing Bai ₁ , Mohammed Y Emran ₂ , Ahmed Kotb ₂ , Xiangjie Bo ₁ , Ming Zhou ₁

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Fully integrated wearable sensors are capable of dynamically, directly, and independently tracking biomarkers in raw noninvasive biofluids without any other equipment or accessories by integrating the unique on-body monitoring feature with the special complete functional implementation attribute. Sweat, saliva, and urine are three important noninvasive biofluids, and changes in their biomarkers hold great potential for revealing physiological conditions. However, it is still a challenge to design single fully integrated wearable sensor arrays (FIWSAs) that are universally able to concurrently measure electrolytes and metabolites in three of the most common noninvasive biofluids including sweat, saliva, and urine. Here, we propose the first single universal FIWSAs for wirelessly, noninvasively, and simultaneously measuring various metabolites (i.e., uric acid) and electrolytes (i.e., Na⁺ and H⁺) in raw sweat, saliva, or urine under subjects’ exercise by integrating the specifically designed microfluidic, sensing, and electronic modules in a seamless manner. We evaluate its utility for noninvasive gout management in healthy subjects and in gout patients through a purine-rich meal challenge and with a medicine-treatment control, respectively. Noninvasive monitoring of multiple electrolytes and metabolites in a variety of raw noninvasive biofluids via such single universal FIWSAs may enrich the understanding of the biomarkers’ levels in the body and would also facilitate self-health management.

中文翻译：

用于原始汗液、唾液或尿液中多种电解质和代谢物监测的通用全集成可穿戴传感器阵列

完全集成的可穿戴传感器能够动态、直接、独立地跟踪原始非侵入性生物流体中的生物标志物，无需任何其他设备或附件，通过集成独特的在体监测特性和特殊的完整功能实现属性。汗液、唾液和尿液是三种重要的非侵入性生物体液，其生物标志物的变化具有揭示生理状况的巨大潜力。然而，设计单个完全集成的可穿戴传感器阵列 (FIWSA) 仍然是一个挑战，该传感器阵列普遍能够同时测量三种最常见的非侵入性生物流体（包括汗液、唾液和尿液）中的电解质和代谢物。在这里，我们提出了第一个用于无线、无创地同时测量各种代谢物（即，⁺和 H ⁺ ) 通过以无缝方式集成专门设计的微流体、传感和电子模块，在受试者运动下的原始汗液、唾液或尿液中。我们分别通过富含嘌呤的膳食挑战和药物治疗对照来评估其在健康受试者和痛风患者中无创痛风管理的效用。通过这种单一的通用 FIWSA 对各种原始非侵入性生物流体中的多种电解质和代谢物进行无创监测，可以丰富对体内生物标志物水平的理解，也有助于自我健康管理。

更新日期：2023-03-24

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