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Stimuli Response of Eu3+-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines
ACS Sensors ( IF 8.2 ) Pub Date : 2023-03-24 , DOI: 10.1021/acssensors.2c02491 Yuval Ben-Shahar 1 , Tamar Shamai Yamin 2 , Sharon Marx 1 , Naama Karton-Lifshin 3 , Daniele Marciano 3
ACS Sensors ( IF 8.2 ) Pub Date : 2023-03-24 , DOI: 10.1021/acssensors.2c02491 Yuval Ben-Shahar 1 , Tamar Shamai Yamin 2 , Sharon Marx 1 , Naama Karton-Lifshin 3 , Daniele Marciano 3
Affiliation
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Metallo-supramolecular polymers offer a highly controllable platform for sensing. Their modular characteristics obtained by the ability of varying both building blocks, the metal ion and the organic ligand, provide tunability of their optical and chemical properties. Specifically, polymers based on lanthanide ions and conjugated aromatic ligands exhibit enhanced luminescence properties that can be altered by external stimulation. Herein, using europium-based polymers, we demonstrate the ability to detect different pharmaceutical amines, including in complex biological media, based on their luminescence quenching efficiency as a result of their polymer dissociation capacity. A combination of absorption, luminescence, and NMR measurements reveals combined static and dynamic quenching mechanisms that enable selective sensing of strong basic amines with high pKa values.
中文翻译：
Eu3+基金属超分子聚合物对药用胺的刺激响应
金属超分子聚合物提供了一个高度可控的传感平台。它们的模块化特征是通过改变两个构建块、金属离子和有机配体的能力获得的，提供了它们的光学和化学性质的可调性。具体而言，基于镧系离子和共轭芳族配体的聚合物表现出增强的发光特性，可以通过外部刺激来改变。在此，使用基于铕的聚合物，我们展示了检测不同药物胺的能力，包括在复杂的生物介质中，基于它们的聚合物解离能力导致的发光猝灭效率。吸收、发光的组合，Ka值。
更新日期：2023-03-24
中文翻译：
Eu3+基金属超分子聚合物对药用胺的刺激响应
金属超分子聚合物提供了一个高度可控的传感平台。它们的模块化特征是通过改变两个构建块、金属离子和有机配体的能力获得的，提供了它们的光学和化学性质的可调性。具体而言，基于镧系离子和共轭芳族配体的聚合物表现出增强的发光特性，可以通过外部刺激来改变。在此，使用基于铕的聚合物，我们展示了检测不同药物胺的能力，包括在复杂的生物介质中，基于它们的聚合物解离能力导致的发光猝灭效率。吸收、发光的组合，Ka值。
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