Direct, stereocontrolled functionalization of ubiquitous C(sp3)–H bonds represents the most efficient route towards highly valuable molecules from feedstock chemicals. Now, diverse, enantioenriched, unnatural α-amino acids are obtained from readily available carboxylic acids in one step via iron-catalysed asymmetric nitrene transfer, overcoming the reactivity and selectivity challenges of intermolecular C–H amination.

中文翻译：

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非天然α-氨基酸合成

无处不在的 C(sp3)–H 键的直接立体控制功能化代表了从原料化学品中获取高价值分子的最有效途径。现在，通过铁催化的不对称氮烯转移一步从容易获得的羧酸中获得多种对映体丰富的非天然 α-氨基酸，克服了分子间 C-H 胺化的反应性和选择性挑战。