Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing,ACS Applied Materials & Interfaces

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Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-03-23 , DOI: 10.1021/acsami.3c01065
Lanlan Wang ₁ , Ziqiang Zhao ₁ , Jinhua Dong ₁ , Dawei Li ₁ , Wenhao Dong ₁ , Haoxuan Li ₁ , Yuqi Zhou ₁ , Qingsheng Liu ₁ , Bingyao Deng ₁

Affiliation

Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against Staphylococcus aureus and Escherichia coli. Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.

中文翻译：

以贻贝为灵感的多功能水凝胶，具有粘附、自愈、抗氧化和抗菌活性，可促进伤口愈合

具有粘附性和抗氧化活性的抗菌水凝胶伤口敷料是治疗临床护理中皮肤损伤的理想选择。在此，利用多巴胺 (DA) 和槲皮素 (QT) 设计并制备了一系列具有高粘附性、自愈性、抗氧化和抗菌活性的多功能水凝胶伤口敷料。多功能水凝胶由互穿的季铵化壳聚糖链段和聚丙烯酰胺网络构成。DA、QT上的儿茶酚基团和水凝胶体系中的季铵基团赋予水凝胶高强度、优异的粘附性和自修复能力。结果证实了多功能水凝胶对金黄色葡萄球菌和大肠杆菌。因此，具有良好粘合和抗菌活性的多功能水凝胶是组织粘合剂和伤口敷料应用领域的合适替代材料。

更新日期：2023-03-23

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