The treatment of water pollution caused by excessive usage of antibiotics has been widely concerned. Periodate (PI)-oxidation method poses a good application prospect for antibiotic degradation with a stable solid oxidant and excellent degradation efficiency. In this study, manganese ferrite (MnFe₂O₄) with superparamagnetic property, low ion leaching, and outstanding activation performance was chosen to active PI to remove ciprofloxacin (CIP) for the first time. And MnFe₂O₄/PI system could achieve 98.8% removal efficiency of 10 mg/L CIP in 90 min (pH = 5.4, 0.3 g/L MnFe₂O₄, 0.2 g/L PI). With the conversion of Fe(II)/Fe(III) and Mn(II)/Mn(III)/Mn(Ⅳ), singlet oxygen (¹O₂), iodate radical (IO₃^•), and superoxide radical (O₂^•−) were formed as the primary active substances to remove CIP. Meanwhile, the redox cycle of Fe(III)/Fe(II) (0.77 V) and Mn(Ⅳ)/Mn(III) (0.15 V) accelerated the process of CIP degradation. Almost 90% of CIP could be removed by MnFe₂O₄/PI system after 5th run, showing the excellent stability of MnFe₂O₄ to activate PI. Besides, MnFe₂O₄/PI system showed tolerance to different background water and selectivity to different antibiotics. This work presents a novel strategy to integrate MnFe₂O₄ with PI for antibiotic-polluted water treatment.

抗生素过量使用造成的水污染治理受到广泛关注。高碘酸盐（PI）-氧化法具有稳定的固体氧化剂和优异的降解效率，在抗生素降解方面具有良好的应用前景。在本研究中，首次选择了具有超顺磁性、低离子浸出和出色活化性能的铁酸锰(MnFe ₂ O _{4 )来活化PI以去除环丙沙星(CIP)。}MnFe ₂ O ₄ /PI体系在90分钟内可达到98.8%的10 mg/L CIP去除效率（pH=5.4，0.3 g/L MnFe ₂ O ₄，0.2 g/L PI）。随着Fe(II)/Fe(III)和Mn(II)/Mn(III)/Mn(IV)的转化，单线态氧( ¹O ₂ )、碘酸根(IO ₃ ^• )和超氧自由基(O ₂ ^•- )作为去除CIP的主要活性物质形成。同时，Fe(III)/Fe(II) (0.77 V) 和 Mn(IV)/Mn(III) (0.15 V) 的氧化还原循环加速了 CIP 的降解过程。_{在第5次运行后，MnFe 2} O ₄ /PI系统可以去除近90%的CIP ，显示出MnFe ₂ O ₄激活PI的优异稳定性。此外，MnFe ₂ O ₄ /PI体系表现出对不同背景水的耐受性和对不同抗生素的选择性。这项工作提出了一种整合 MnFe ₂ O _{4的新策略}与 PI 一起用于抗生素污染的水处理。