An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability,Chemistry - An Asian Journal

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An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2023-03-21 , DOI: 10.1002/asia.202300044
Nidhi Gour ₁ , Vivekshinh Kshtriya ₁ , Sajmina Khatun ₂ , Sujoy Bandyopadhyay ₁ , Rajib Ghosh _{3,

4} , Bharti Koshti ₁ , Ramesh Singh _{5,

6} , Ashadul Haque ₅ , Dhiraj Bhatia ₆ , Khashti Ballabh Joshi ₅ , Danil W Boukhvalov _{7,

8} , Sukhendu Nath _{3,

4} , Aravind K Rengan ₂

Affiliation

We report the photophysical properties, self-assembly and biological evaluation of an isothiazolanthrone based dye 7-Amino-6H-anthra[9,1-cd]isothiazol-6-one (AAT) which can be potentially used for concurrent imaging and monitoring of cell viability. Interestingly, AAT reveals anticancer properties due to which it can detect cancer cell differentially as compared to normal cells.

中文翻译：

一种基于异噻唑啉酮的自组装抗癌变色染料，用于同时成像和监测细胞活力

我们报告了基于异噻唑啉酮的染料 7-Amino-6H-anthra[9,1-cd]isothiazol-6-one ( AAT ) 的光物理特性、自组装和生物学评价，它可用于同时成像和监测细胞活力。有趣的是，AAT揭示了抗癌特性，因此与正常细胞相比，它可以差异化地检测癌细胞。

更新日期：2023-03-21

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