Pretransmetalation Intermediates in Suzuki–Miyaura Cross-Couplings: Synthesis of Csp3-, Csp2- and Csp-Organopalladium(II) Boronates,Inorganic Chemistry

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Pretransmetalation Intermediates in Suzuki–Miyaura Cross-Couplings: Synthesis of Csp3-, Csp2- and Csp-Organopalladium(II) Boronates
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2023-03-22 , DOI: 10.1021/acs.inorgchem.3c00198
Angus Olding ₁ , Curtis C Ho ₁ , Nigel T Lucas ₂ , Alex C Bissember ₁

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Organopalladium(II) boronates represent fundamental pretransmetalation intermediates in Suzuki–Miyaura cross-couplings. These species are typically kinetically unstable, making them particularly elusive. In this study, a range of unprecedented, kinetically stable alkyl-, alkenyl-, allenyl-, and alkynylpalladium(II) boronates were prepared from various C_sp³, C_sp², and C_sp electrophiles via a simple, general method. The structures of these complexes were secured by X-ray crystallography, and the chemical competence of a number of these intermediates in transmetalation was demonstrated.

中文翻译：

Suzuki-Miyaura 交叉偶联中的预转金属中间体：Csp3-、Csp2- 和 Csp-有机钯 (II) 硼酸盐的合成

有机钯 (II) 硼酸盐代表铃木-宫浦交叉偶联中的基本预金属化中间体。这些物种通常在动力学上不稳定，使它们特别难以捉摸。在这项研究中，通过简单、通用的方法从各种 C _{sp ³}、C _{sp ²}和 C _sp亲电子试剂制备了一系列前所未有的、动力学稳定的烷基-、烯基-、丙二烯基-和炔基钯 (II) 硼酸盐。这些复合物的结构由 X 射线晶体学确定，并且证明了许多这些中间体在金属转移中的化学能力。

更新日期：2023-03-22

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