仿生矿化：从微观到宏观材料及其生物医学应用,ACS Applied Bio Materials

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仿生矿化：从微观到宏观材料及其生物医学应用
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2023-03-21 , DOI: 10.1021/acsabm.3c00109
Yusai Zhou ₁ , Kai Liu _{1,

2} , Hongjie Zhang _{1,

2}

Affiliation

生物矿化是生产具有高性能和分层结构的矿物基生物材料的一种有吸引力的途径。迄今为止，生物矿化过程和机制已得到广泛研究，特别是骨、牙齿和珍珠层的形成。受这些启发，人们已经制造出丰富的仿生矿化材料用于生物医学应用。这些仿生材料通常表现出良好的机械性能和生物功能。然而，仿生材料和天然材料之间仍然存在巨大差距，特别是在机械性能和多尺度结构方面。本文从材料合成和生物医学应用的角度总结了微观和宏观仿生矿化的最新进展。首先，我们讨论微观水平上仿生矿化的进展。通过引入 DNA 纳米结构、纳米疫苗和活细胞等生物矿物质，纳米和微米材料的机械强度、稳定性和功能得到显着改善。接下来，重点介绍了许多基于宏观尺度生物矿化的仿生策略，包括原位矿化和矿化构件的自下而上组装。最后，还提出了仿生矿化发展的挑战和未来前景，旨在为下一代仿生矿化材料的合理设计和制造提供见解。

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Biomimetic Mineralization: From Microscopic to Macroscopic Materials and Their Biomedical Applications

Biomineralization is an attractive pathway to produce mineral-based biomaterials with high performance and hierarchical structures. To date, the biomineralization process and mechanism have been extensively studied, especially for the formation of bone, teeth, and nacre. Inspired by those, abundant biomimetic mineralized materials have been fabricated for biomedical applications. Those bioinspired materials generally exhibit great mechanical properties and biological functions. Nevertheless, substantial gaps remain between biomimetic materials and natural materials, particularly with respect to mechanical properties and mutiscale structures. This Review summarizes the recent progress of micro- and macroscopic biomimetic mineralization from the perspective of materials synthesis and biomedical applications. To begin with, we discuss the progress of biomimetic mineralization at the microscopic level. The mechanical strength, stability, and functionality of the nano- and micromaterials are significantly improved by introducing biominerals, such as DNA nanostructures, nanovaccines, and living cells. Next, numerous biomimetic strategies based on biomineralization at the macroscopic scale are highlighted, including in situ mineralization and bottom-up assembly of mineralized building blocks. Finally, challenges and future perspectives regarding the development of biomimetic mineralization are also presented with the aim of offering insights for the rational design and fabrication of next-generation biomimetic mineralized materials.

更新日期：2023-03-21

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