具有抗菌和抗氧化双重功能的铜纳米点离子凝胶用于大鼠牙周炎深层组织渗透治疗,Biomaterials Science

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具有抗菌和抗氧化双重功能的铜纳米点离子凝胶用于大鼠牙周炎深层组织渗透治疗
Biomaterials Science ( IF 5.8 ) Pub Date : 2023-03-21 , DOI: 10.1039/d3bm00309d
Yiru Gao ₁ , Wenxin Zhang ₁ , Rong Xue ₁ , Yang Shu ₁ , Jianhua Wang ₁

Affiliation

牙周炎的局部治疗由于具有全身副作用小、局部药物浓度高等优点，近来受到广泛关注。但局部给药系统在临床实践中应用并不广泛，主要障碍是组织通透性差。在本研究中，我们报道了一种基于铜纳米点的离子凝胶（Cu-NDs/IL 凝胶），它具有良好的组织穿透能力，同时具有抗菌和抗炎功能。通过将具有三重酶样活性的铜纳米点 (Cu-NDs) 加载到多功能凝胶中，制备了 Cu-NDs/IL 凝胶。衍生的 Cu-NDs/IL 凝胶具有显着的抗菌性能，这归因于 Cu-NDs 的过氧化物酶样活性。此外，Cu-NDs 模拟超氧化物歧化酶和过氧化氢酶活性，赋予凝胶在中性环境下优异的自由基清除能力，缓解牙周炎症。更重要的是，Cu-NDs/IL 凝胶中的 IL 部分促进 Cu-NDs 渗透到牙龈组织中，其中 Cu-NDs 的三重酶活性可能起作用。简而言之，Cu-NDs/IL 凝胶通过促进渗透、杀灭细菌和清除 ROS，有望成为牙周炎的局部用药。

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An ionic gel incorporating copper nanodots with antibacterial and antioxidant dual functions for deep tissue penetration treatment of periodontitis in rats

The local treatment of periodontitis has recently received extensive attention due to the advantages of mild systemic side effects and a high local drug concentration. But the local drug delivery systems are not widely used in clinical practice, and a major obstacle is the poor tissue permeability. In the present study, we report a copper nanodot based ionic gel (Cu-NDs/IL gel) with favorable tissue penetration capability, and it concurrently exhibits antibacterial and anti-inflammatory functions. A Cu-NDs/IL gel was prepared by loading copper nanodots (Cu-NDs) with triple enzyme-like activities into a multifunctional gel. The derived Cu-NDs/IL gel possesses remarkable antibacterial properties attributed to the peroxidase-like activity of Cu-NDs. In addition, Cu-NDs mimic superoxide dismutase and catalase activities, which endow the gel with excellent free radical scavenging capability in a neutral environment to relieve periodontal inflammation. More importantly, the IL moiety in the Cu-NDs/IL gel promotes the penetration of Cu-NDs into the gingival tissue, wherein the triple enzymatic activity of Cu-NDs may function. In short, the Cu-NDs/IL gel has promising potential to serve as a topical drug for periodontitis by promoting penetration, killing bacteria, and scavenging ROS.

更新日期：2023-03-21

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