Electrodeposited NaYF4:Yb3+, Er3+ up-conversion films for flexible neural device construction and near-infrared optogenetics,Journal of Materials Chemistry B

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Electrodeposited NaYF4:Yb3+, Er3+ up-conversion films for flexible neural device construction and near-infrared optogenetics
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-03-20 , DOI: 10.1039/d2tb02665a
Xuran Zhang _{1,

2,

3} , Jianfei Ding ₁ , Liang Zou _{1,

2,

3} , Huihui Tian ₁ , Ying Fang _{1,

2,

3,

4} , Jinfen Wang ₁

Affiliation

Near-infrared optogenetics based on up-conversion materials provides a promising tool for the dissection of neural circuit functions in deep brain regions. However, it remains a challenge to combine near-infrared up-conversion optogenetic stimulation with high-density electrophysiological recording in a minimally invasive manner. Here, we develop a flexible device for simultaneous electrophysiological recording and near-infrared optogenetics. The flexible device is constructed by integrating polymer-based flexible recording microelectrodes with electrodeposited NaYF₄:Yb³⁺, Er³⁺ up-conversion films that can convert deep-tissue-penetrating near-infrared light into visible light for optogenetic activation of C1V1-expressing neurons. The emission properties of the up-conversion films are optimized for green light emission to stimulate C1V1 opsins. Owing to their minimized surgical footprint and high mechanical compliance, chronically implanted devices enable simultaneous electrophysiological recording and near-infrared optogenetic modulation of neuronal activities in the brain.

中文翻译：

用于柔性神经装置构建和近红外光遗传学的电沉积 NaYF4:Yb3+、Er3+ 上转换薄膜

基于上转换材料的近红外光遗传学为剖析大脑深部区域的神经回路功能提供了一种有前景的工具。然而，以微创方式将近红外上转换光遗传学刺激与高密度电生理记录结合起来仍然是一个挑战。在这里，我们开发了一种用于同时电生理记录和近红外光遗传学的灵活设备。该柔性装置是通过将基于聚合物的柔性记录微电极与电沉积的NaYF ₄ :Yb ³⁺ , Er ^{3+集成而构建的}上转换薄膜可以将穿透深层组织的近红外光转换为可见光，用于表达 C1V1 的神经元的光遗传学激活。上转换膜的发射特性针对绿光发射进行了优化，以刺激 C1V1 视蛋白。由于其最小化的手术足迹和较高的机械顺应性，长期植入的设备能够同时对大脑中的神经元活动进行电生理记录和近红外光遗传学调节。

更新日期：2023-03-20

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