具有高抗菌负载效率和 pH 响应特性的多功能水凝胶涂层，适用于导尿管应用,Journal of Materials Chemistry B

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具有高抗菌负载效率和 pH 响应特性的多功能水凝胶涂层，适用于导尿管应用
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-03-20 , DOI: 10.1039/d3tb00148b
Jiru Miao _{1,

2} , Xiang Wu _{2,

3} , Yue Fang ₂ , Mingzhu Zeng ₂ , Zhimao Huang ₂ , Mi Ouyang ₁ , Rong Wang _{2,

4}

Affiliation

导管相关尿路感染是最常见的医院获得性感染之一。结壳的形成是由产生脲酶的细菌感染引起的，并使情况进一步复杂化。结垢形成初期的典型症状是尿液碱化（pH 值高达 9-10）。然而，仍然缺乏具有高抗菌负载效率和抗菌剂释放 pH 响应性的有效抗菌策略。在这项研究中，我们开发了一种聚（磺基甜菜碱甲基丙烯酸酯）-单宁酸（polySBMA-TA）水凝胶涂层，它可作为导尿管抗菌药物的通用、高效和响应性载体。通过在聚(乙烯基吡咯烷酮)-碘、铜离子和呋喃西林之间形成多种非共价相互作用，将常见的抗菌剂高效负载到聚SBMA-TA涂层中（比聚SBMA涂层高数倍）。抗菌剂和水凝胶涂层。水凝胶涂层在中性条件下保持良好的抗菌性能。更重要的是，碱性条件下抗菌剂的pH响应性释放进一步增强了涂层的抗菌活性，有利于杀死产生脲酶的细菌并防止结垢。体外和体内试验证实水凝胶涂层具有良好的生物相容性，能够有效抑制细菌定植和结壳形成。这项研究为利用简单且通用的负载抗菌剂的水凝胶涂层提供了新的机会，该涂层具有智能的 pH 响应特性，可对抗导尿管中的细菌定植和结壳形成。

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Multifunctional hydrogel coatings with high antimicrobial loading efficiency and pH-responsive properties for urinary catheter applications

Catheter-associated urinary tract infections are one of the most common hospital-acquired infections. Encrustation formation results from infection of urease-producing bacteria and further complicates the situation. A typical sign of the initial onset of encrustation formation is the alkalization of the urine (pH up to 9–10). However, effective antibacterial strategies with high antimicrobial loading efficiency and pH-responsiveness of antimicrobial release are still lacking. In this study, we developed a poly(sulfobetaine methacrylate)-tannic acid (polySBMA-TA) hydrogel coating, which served as a universal, efficient, and responsive carrier for antimicrobials on urinary catheters. Common antimicrobials, including poly(vinylpyrrolidone)-iodine, copper ions, and nitrofurazone were loaded into the polySBMA-TA coating in high efficiency (several fold higher than that of the polySBMA coating), via the formation of multiple non-covalent interactions between the antimicrobials and hydrogel coating. The hydrogel coatings maintained good antibacterial properties under neutral conditions. More importantly, the pH-responsive release of antibacterial agents under alkaline conditions further enhanced the antibacterial activity of the coatings, which was advantageous for killing the urease-producing bacteria and preventing encrustation. In vitro and in vivo tests confirmed that the hydrogel coating has good biocompatibility, and could effectively inhibit bacterial colonization and encrustation formation. This study offers new opportunities for the utilization of a simple and universal antimicrobial-loaded hydrogel coating with smart pH-responsive properties to combat bacterial colonization and encrustation formation in urinary catheters.

更新日期：2023-03-20

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