聚电解质增韧双网络水凝胶,Advanced Materials

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聚电解质增韧双网络水凝胶
Advanced Materials ( IF 27.4 ) Pub Date : 2023-03-20 , DOI: 10.1002/adma.202301551
Mengyuan Zhang ₁ , Yuxuan Yang ₂ , Meng Li ₁ , Qinghua Shang ₁ , Ruilin Xie ₁ , Jing Yu ₁ , Kaixiang Shen ₁ , Yanfeng Zhang ₁ , Yilong Cheng _{1,

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Affiliation

无机盐的霍夫迈斯特效应被证实是一种有前途的增韧水凝胶的方法，然而，高浓度的无机盐可能伴随着较差的生物相容性。在这项工作中，发现聚电解质可以通过霍夫迈斯特效应明显提高水凝胶的机械性能。将阴离子聚丙烯酸钠引入到聚乙烯醇（PVA）水凝胶中会引起PVA的聚集和结晶，从而提高所得双网络水凝胶的机械性能：提高73、64、28、135，拉伸强度、压缩强度、杨氏模量、韧性、断裂能分别是聚丙烯酸的19倍。值得注意的是，水凝胶的机械性能可以通过聚电解质浓度、电离度、离子组分的相对疏水性和聚电解质类型在大范围内的变化来灵活调节。该策略已被证实适用于其他霍夫迈斯特效应敏感的聚合物和聚电解质。此外，在聚电解质中引入脲键可以进一步提高水凝胶的力学性能和抗溶胀能力。作为一种生物医学补片，先进的水凝胶可以有效抑制腹壁缺损模型中疝气的形成并促进软组织的再生。该策略已被证实适用于其他霍夫迈斯特效应敏感的聚合物和聚电解质。此外，在聚电解质中引入脲键可以进一步提高水凝胶的力学性能和抗溶胀能力。作为一种生物医学补片，先进的水凝胶可以有效抑制腹壁缺损模型中疝气的形成并促进软组织的再生。该策略已被证实适用于其他霍夫迈斯特效应敏感的聚合物和聚电解质。此外，在聚电解质中引入脲键可以进一步提高水凝胶的力学性能和抗溶胀能力。作为一种生物医学补片，先进的水凝胶可以有效抑制腹壁缺损模型中疝气的形成并促进软组织的再生。

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Toughening Double-Network Hydrogels by Polyelectrolytes

The Hoffmeister effect of inorganic salts is verified as a promising way to toughen hydrogels, however, the high concentration of inorganic salts may be accompanied by poor biocompatibility. In this work, it is found that polyelectrolytes can obviously elevate the mechanical performances of hydrogels through the Hoffmeister effect. The introduction of anionic poly(sodium acrylate) into poly(vinyl alcohol) (PVA) hydrogel induces the aggregation and crystallization of the PVA to boost the mechanical properties of the resulting double-network hydrogel: elevation of 73, 64, 28, 135, and 19 times in the tensile strength, compressive strength, Young's modulus, toughness, and fracture energy compared with poly(acrylic acid), respectively. It is noteworthy that the mechanical performances of the hydrogels can be flexibly tuned by the variation of polyelectrolyte concentration, ionization degree, relative hydrophobicity of the ionic component, and polyelectrolyte type in a wide range. This strategy is verified to work for other Hoffmeister-effect-sensitive polymers and polyelectrolytes. Also, the introduction of urea bonds into the polyelectrolyte can further improve the mechanical properties and antiswelling capability of hydrogels. As a biomedical patch, the advanced hydrogel can efficiently inhibit hernia formation and promote the regeneration of soft tissues in an abdominal wall defect model.

更新日期：2023-03-20

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