雄性偏头痛大鼠导水管周围灰质与双侧三叉神经尾核不对称调节相关性的研究,The Journal of Headache and Pain

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雄性偏头痛大鼠导水管周围灰质与双侧三叉神经尾核不对称调节相关性的研究
The Journal of Headache and Pain ( IF 7.3 ) Pub Date : 2023-03-20 , DOI: 10.1186/s10194-023-01559-4
Zhijian Cao _{1,

2} , Wenjing Yu _{1,

2} , Luping Zhang ₃ , Jiajia Yang _{1,

2} , Jiafei Lou _{1,

2} , Maosheng Xu _{1,

2} , Zhengxiang Zhang _{1,

4}

Affiliation

本研究旨在通过研究急性偏头痛发作时疼痛调节通路代谢产物的变化，探讨偏头痛大鼠导水管周围灰质（PAG）与双侧三叉神经尾核（TNC）不对称调节的相关性。将 30 只雄性 Sprague-Dawley (SD) 大鼠随机分为三组：空白组、对照组、模型组。然后,空白组腹腔注射超纯水,对照组注射生理盐水,模型组注射三硝酸甘油酯(GTN)。2小时后，分别去除PAG和双侧TNC，得到PAG、Left-TNC、Right-TNC的代谢物浓度。最后，比较了三种脑组织中代谢产物的差异。rNAA、rGlu、rGln、rTau、PAG 或双边 TNC 中的 rMI 在组和站点之间具有交互作用。偏头痛大鼠三种脑组织rLac浓度升高，但LTNC和RTNC的rLac升高幅度大于PAG。此外，rNAA 和 rGln 的浓度在 RTNC 中升高，而 rGABA 在 RTNC 中降低。PAG、LTNC和RTNC在急性偏头痛发作时对疼痛的调节存在相关性，LTNC和RTNC对疼痛的调节是不对称的。

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A study on the correlation of the asymmetric regulation between the periaqueductal gray and the bilateral trigeminal nucleus caudalis in migraine male rats

The study was designed to explore the correlation of the asymmetric regulation between periaqueductal gray (PAG) and bilateral trigeminal nucleus caudalis (TNC) in migraine rats through studying the changes of metabolites in pain regulatory pathway of acute migraine attack. Thirty male Sprague–Dawley (SD) rats were randomly divided into three groups: blank, control, model groups. Then, blank group was intraperitoneally injected with ultrapure water, while control group injected with saline and model group injected with Glyceryl Trinitrate (GTN). Two hours later, PAG and bilateral TNC were removed respectively, and metabolite concentrations of PAG, Left-TNC, Right-TNC were obtained. Lastly, the differences of metabolite among three brain tissues were compared. The relative concentrations of rNAA, rGlu, rGln, rTau, rMI in PAG or bilateral TNC had interaction effects between groups and sites. The concentration of rLac of three brain tissues increased in migraine rats, however, the rLac of LTNC and RTNC increased more than that of PAG. Besides, the concentrations of rNAA and rGln increased in RTNC, while rGABA decreased in RTNC. There is correlation between PAG, LTNC and RTNC in regulation of pain during acute migraine attack, and the regulation of LTNC and RTNC on pain is asymmetric.

更新日期：2023-03-20

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