SMC4，一种新型肿瘤预后标志物和潜在的肿瘤治疗靶点,Frontiers in Oncology

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SMC4，一种新型肿瘤预后标志物和潜在的肿瘤治疗靶点
Frontiers in Oncology ( IF 3.5 ) Pub Date : 2023-03-17 , DOI: 10.3389/fonc.2023.1117642
Zonglei Zhao ₁ , Xixiu Wang ₂ , Yan Ding ₁ , Xuefeng Cao ₁ , Xingyuan Zhang ₁

Affiliation

4 号染色体 (SMC4) 的结构维护是染色体 ATPase 家族的成员。SMC4 以及整个凝聚蛋白复合物的其余亚基最广泛报道的功能是姐妹染色单体的压缩和解离、DNA 损伤修复、DNA 重组和基因组的普遍转录。研究还表明，SMC4在胚胎细胞的分裂周期中起着极其重要的作用，如RNA剪接、DNA代谢过程、细胞粘附和细胞外基质等。另一方面，SMC4也是炎症性先天免疫反应的正调节因子，而过度的先天免疫反应不仅会破坏免疫稳态，还可能导致自身免疫性疾病，甚至癌症。为进一步了解SMC4在肿瘤中的表达及预后价值，我们提供了对文献和几个生物信息学数据库的深入回顾，例如癌症基因组图谱 (TCGA)、基因型组织表达 (GTEx)、临床蛋白质组肿瘤分析联盟 (CPTAC)、人类蛋白质图谱和 Kaplan Meier绘图工具，说明 SMC4 在肿瘤的发生和发展中起着至关重要的作用，SMC4 的高表达似乎始终预示着更差的总生存期。综上所述，本综述详细介绍了SMC4的结构、生物学功能及其与肿瘤的相关性；它可能为新的肿瘤预后标志物和潜在的肿瘤治疗靶点提供新的见解。Clinical Proteomic Tumor Analysis Consortium (CPTAC)、The Human Protein Atlas 和 Kaplan Meier plotter 工具，说明 SMC4 在肿瘤的发生和发展中起着至关重要的作用，SMC4 的高表达似乎始终预示着较差的总生存期。综上所述，本综述详细介绍了SMC4的结构、生物学功能及其与肿瘤的相关性；它可能为新的肿瘤预后标志物和潜在的肿瘤治疗靶点提供新的见解。Clinical Proteomic Tumor Analysis Consortium (CPTAC)、The Human Protein Atlas 和 Kaplan Meier plotter 工具，说明 SMC4 在肿瘤的发生和发展中起着至关重要的作用，SMC4 的高表达似乎始终预示着较差的总生存期。综上所述，本综述详细介绍了SMC4的结构、生物学功能及其与肿瘤的相关性；它可能为新的肿瘤预后标志物和潜在的肿瘤治疗靶点提供新的见解。本综述详细介绍了SMC4的结构、生物学功能及其与肿瘤的相关性；它可能为新的肿瘤预后标志物和潜在的肿瘤治疗靶点提供新的见解。本综述详细介绍了SMC4的结构、生物学功能及其与肿瘤的相关性；它可能为新的肿瘤预后标志物和潜在的肿瘤治疗靶点提供新的见解。

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SMC4, a novel tumor prognostic marker and potential tumor therapeutic target

The structural maintenance of chromosome 4 (SMC4) is a member of the ATPase family of chromosomes. The most widely reported function of SMC4, as well as the remaining subunits of whole condensin complexes, is compression and dissociation of sister chromatids, DNA damage repair, DNA recombination, and pervasive transcription of the genome. Studies have also shown that SMC4 plays an exceedingly essential role in the division cycle of embryonic cells, such as RNA splicing, DNA metabolic process, cell adhesion, and extracellular matrix. On the other hand, SMC4 is also a positive regulator of the inflammatory innate immune response, while excessive innate immune responses not only disrupt immune homeostasis and may lead to autoimmune diseases, but even cancer. To further understand the expression and prognostic value of SMC4 in tumors, we provide an in-depth review of the literature and several bioinformatic databases, for example, The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analysis Consortium (CPTAC), The Human Protein Atlas and Kaplan Meier plotter tools, illustrating that SMC4 plays a vital role in the occurrence and development of tumors, and high expression of SMC4 seems to consistently predict worse overall survival. In conclusion, we present this review which introduces the structure, biological function of SMC4, and its correlation with the tumor in detail; it might provide new insight into a novel tumor prognostic marker and potential tumor therapeutic target.

更新日期：2023-03-17

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