Osteoarthritis (OA) is the most common debilitating joint disease, yet there is no curative treatment for OA to date. Delivering mesenchymal stromal cells (MSCs) as therapeutic cells to mitigate the inflammatory symptoms associated with OA is attracting increasing attention. In principle, MSCs could respond to the pro-inflammatory microenvironment of an OA joint by the secretion of anti-inflammatory, anti-apoptotic, immunomodulatory and pro-regenerative factors, therefore limiting pain, as well as the disease development. However, the microenvironment of MSCs is known to greatly affect their survival and bioactivity, and using tailored biomaterial scaffolds could be key to the success of intra-articular MSC-based therapies. The aim of this review is to identify and discuss essential characteristics of biomaterial scaffolds to best promote MSC secretory functions in the context of OA. First, a brief introduction to the OA physiopathology is provided, followed by an overview of the MSC secretory functions, as well as the current limitations of MSC-based therapy. Then, we review the current knowledge on the effects of cell-material interactions on MSC secretion. These considerations allow us to define rational guidelines for next-generation biomaterial design to improve the MSC-based therapy of OA.

骨关节炎 (OA) 是最常见的使人衰弱的关节疾病，但迄今为止还没有治愈 OA 的方法。递送间充质基质细胞 (MSC) 作为治疗细胞以减轻与 OA 相关的炎症症状正引起越来越多的关注。原则上，MSCs 可以通过分泌抗炎、抗凋亡、免疫调节和促再生因子来响应 OA 关节的促炎微环境，从而限制疼痛和疾病发展。然而，已知 MSC 的微环境会极大地影响它们的存活和生物活性，使用定制的生物材料支架可能是关节内 MSC 疗法成功的关键。本综述的目的是确定和讨论生物材料支架的基本特征，以在 OA 的背景下最好地促进 MSC 分泌功能。首先，简要介绍了 OA 的生理病理学，然后概述了 MSC 的分泌功能，以及目前基于 MSC 的治疗的局限性。然后，我们回顾了当前关于细胞-物质相互作用对 MSC 分泌的影响的知识。这些考虑使我们能够为下一代生物材料设计定义合理的指导方针，以改进基于 MSC 的 OA 治疗。我们回顾了当前关于细胞-物质相互作用对 MSC 分泌的影响的知识。这些考虑使我们能够为下一代生物材料设计定义合理的指导方针，以改进基于 MSC 的 OA 治疗。我们回顾了当前关于细胞-物质相互作用对 MSC 分泌的影响的知识。这些考虑使我们能够为下一代生物材料设计定义合理的指导方针，以改进基于 MSC 的 OA 治疗。