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Tough, Recyclable, and Degradable Elastomers for Potential Biomedical Applications
Advanced Materials ( IF 27.4 ) Pub Date : 2023-03-16 , DOI: 10.1002/adma.202210092 Xiwei Guo 1 , Jiaheng Liang 2 , Zhifen Wang 3 , Jianliang Qin 1 , Qi Zhang 1 , Shiping Zhu 1 , Kun Zhang 2 , He Zhu 1
Advanced Materials ( IF 27.4 ) Pub Date : 2023-03-16 , DOI: 10.1002/adma.202210092 Xiwei Guo 1 , Jiaheng Liang 2 , Zhifen Wang 3 , Jianliang Qin 1 , Qi Zhang 1 , Shiping Zhu 1 , Kun Zhang 2 , He Zhu 1
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Elastomers have many industrial, medical and commercial applications, however, their huge demand raises an important question of how to dispose of the out-of-service elastomers. Ideal elastomers that are concurrently tough, recyclable, and degradable are in urgent need, but their preparation remains a rigorous challenge. Herein, a polycaprolactone (PCL) based polyurethane elastomer is designed and prepared to meet this demand. Owing to the presence of dynamic coordination bond and the occurrence of strain-induced crystallization, the obtained elastomer exhibits a high toughness of ≈372 MJ m−3 and an unprecedented fracture energy of ≈646 kJ m−2, which is much higher than natural rubber (≈50 MJ m−3 for toughness and ≈10 kJ m−2 for fracture energy). In addition, the elastomer can be recycled at least three times using solvent without losing its mechanical properties and can be degraded by lipase in ≈2 months. Finally, biological experiments demonstrate that the elastomer possesses good biocompatibility and can facilitate wound healing in mice when used as sutures. It is believed that the obtained elastomer meets the requirements for next-generation elastomers and is expected to be used in emerging fields such as biomedicine, flexible electronics, robotics and beyond.
中文翻译：
用于潜在生物医学应用的坚韧、可回收和可降解的弹性体
弹性体有许多工业、医疗和商业应用，然而，它们的巨大需求引发了一个重要问题，即如何处理报废的弹性体。迫切需要同时坚韧、可回收和可降解的理想弹性体，但它们的制备仍然是一项严峻的挑战。在此，设计并制备了一种基于聚己内酯 (PCL) 的聚氨酯弹性体来满足这一需求。由于动态配位键的存在和应变诱导结晶的发生，所得弹性体具有≈372 MJ m −3的高韧性和≈646 kJ m −2前所未有的断裂能，远高于天然弹性体橡胶（≈50 MJ m -3韧性和≈10 kJ m -2为断裂能）。此外，弹性体可以使用溶剂至少回收三次而不会失去其机械性能，并且可以在约 2 个月内被脂肪酶降解。最后，生物学实验表明，弹性体具有良好的生物相容性，用作缝合线时可以促进小鼠伤口的愈合。相信所获得的弹性体符合下一代弹性体的要求，有望应用于生物医学、柔性电子、机器人等新兴领域。
更新日期：2023-03-16
中文翻译：
用于潜在生物医学应用的坚韧、可回收和可降解的弹性体
弹性体有许多工业、医疗和商业应用，然而，它们的巨大需求引发了一个重要问题，即如何处理报废的弹性体。迫切需要同时坚韧、可回收和可降解的理想弹性体，但它们的制备仍然是一项严峻的挑战。在此，设计并制备了一种基于聚己内酯 (PCL) 的聚氨酯弹性体来满足这一需求。由于动态配位键的存在和应变诱导结晶的发生，所得弹性体具有≈372 MJ m −3的高韧性和≈646 kJ m −2前所未有的断裂能，远高于天然弹性体橡胶（≈50 MJ m -3韧性和≈10 kJ m -2为断裂能）。此外，弹性体可以使用溶剂至少回收三次而不会失去其机械性能，并且可以在约 2 个月内被脂肪酶降解。最后，生物学实验表明，弹性体具有良好的生物相容性，用作缝合线时可以促进小鼠伤口的愈合。相信所获得的弹性体符合下一代弹性体的要求，有望应用于生物医学、柔性电子、机器人等新兴领域。
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