Introduction

Cognition refers to brain functions including memory, learning, and thought processing and is increasingly important to individuals. However, impairment of cognitive function is a concern among North American adults. Therefore, effective and reliable treatments are needed.

Methods

This randomized, double-blind, placebo-controlled study examined the effects of 42 days of Neuriva® supplementation, a whole coffee cherry extract and phosphatidylserine supplement, on memory, accuracy, focus and concentration and learning among 138 healthy adults (40–65 years) with self-reported memory problems. Plasma brain-derived neurotrophic factor (BDNF) levels, Computerized Mental Performance Assessment System (COMPASS) tasks, the Everyday Memory Questionnaire (EMQ), and Go/No-Go tests were assessed at baseline and day 42.

Results

As compared to placebo, Neuriva® supplementation elicited greater improvements at day 42 in numeric working memory COMPASS task accuracy outcomes (p ≤ 0.024) which assessed memory, accuracy, and focus and concentration, and reaction time outcomes (p ≤ 0.031) which assessed memory as well as focus and concentration. Neuriva® supplementation improved overall accuracy (p = 0.035) in the picture recognition task that assessed memory, accuracy, and learning compared to placebo. No significant differences between groups were observed for BDNF, the EMQ, or Go/No-Go tests.

Conclusion

Results suggest 42 days of Neuriva® supplementation was safe, well tolerated, and beneficial in improving memory, accuracy, focus and concentration, and learning in a healthy adult population with self-reported memory problems.

中文翻译：

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一项随机、双盲、安慰剂对照、平行研究，调查全咖啡樱桃提取物和磷脂酰丝氨酸制剂对有自我感知记忆问题的健康成年人认知能力的功效

介绍

认知是指包括记忆、学习和思维处理在内的大脑功能，对个人来说越来越重要。然而，认知功能受损是北美成年人关注的问题。因此，需要有效和可靠的治疗方法。

方法

这项随机、双盲、安慰剂对照研究调查了 42 天 Neuriva® 补充剂、全咖啡果提取物和磷脂酰丝氨酸补充剂对 138 名健康成年人（40-65 岁）的记忆力、准确性、专注力和注意力以及学习的影响) 与自我报告的内存问题。在基线和第 42 天评估血浆脑源性神经营养因子 (BDNF) 水平、计算机化心理表现评估系统 (COMPASS) 任务、日常记忆问卷 (EMQ) 和 Go/No-Go 测试。

结果

与安慰剂相比，Neuriva® 补充剂在第 42 天引起了数字工作记忆 COMPASS 任务准确性结果（p  ≤ 0.024）（评估记忆力、准确性、专注力和注意力）以及反应时间结果（p  ≤ 0.031）（评估记忆力）的更大改善以及注意力和注意力。 与安慰剂相比，Neuriva® 补充剂提高了评估记忆力、准确性和学习能力的图片识别任务的整体准确性 ( p = 0.035)。对于 BDNF、EMQ 或 Go/No-Go 测试，未观察到组间的显着差异。

结论

结果表明 42 天的 Neuriva® 补充剂是安全的、耐受性良好的，并且有益于提高记忆力、准确性、专注力和注意力，以及在自我报告有记忆问题的健康成年人群中的学习。