Encapsulation of Lacto-N-biose based on ovalbumin and carboxymethyl cellulose microparticles: fabrication, characterisation and thermal stability,International Journal of Food Science & Technology

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Encapsulation of Lacto-N-biose based on ovalbumin and carboxymethyl cellulose microparticles: fabrication, characterisation and thermal stability
International Journal of Food Science & Technology ( IF 2.6 ) Pub Date : 2023-03-14 , DOI: 10.1111/ijfs.16409
Xin Huang ₁ , Yue Sun ₁ , Suhong Li ₁ , Motomitsu Kitaoka ₂ , Tuoping Li ₁

Affiliation

To improve the thermal stability Lacto-N-biose (LNB), it was encapsulated by the OVA-CMC microparticles system. When the mass ratio of OVA:CMC:LNB was 1.5:1:1, the particle size of microparticles was 623 ± 4 nm, and the encapsulation efficiency and loading efficiency of 83 ± 1.38% and 45 ± 0.92% respectively. Analysis with the scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) revealed that the OVA-CMC-LNB microparticles were spherical and uniformly distributed. The hydrogen bonding and electrostatic interactions were the main forces to assemble the microparticles. The results of the thermogravimetric analysis showed that the structure of microparticles remained stable at 240 °C. The residual amount of LNB in microparticles reached 94.3 ± 1.03% and 78.8 ± 2.38% after being heated at 90 °C for 10 and 30 min, and the thermal stability was greatly improved. In vitro simulated digestion experiments showed that the release rate of LNB in microparticles reached 95 ± 1.31%. These results provided a theoretical and technological approach for the construction of LNB delivery system improved thermal stability.

中文翻译：

基于卵清蛋白和羧甲基纤维素微粒的乳-N-二糖包封：制造、表征和热稳定性

为了提高乳-N-二糖 (LNB) 的热稳定性，它被 OVA-CMC 微粒系统封装。当OVA:CMC:LNB质量比为1.5:1:1时，微粒粒径为623±4nm，包封率和负载率分别为83±1.38%和45±0.92%。扫描电子显微镜 (SEM)、傅里叶变换红外光谱 (FT-IR) 和 X 射线衍射 (XRD) 分析表明，OVA-CMC-LNB 微粒呈球形且分布均匀。氢键和静电相互作用是组装微粒的主要力量。热重分析结果表明，微粒的结构在 240 °C 时保持稳定。LNB在微粒中的残留量达到94.3±1.03%和78.8±2。体外模拟消化实验表明，LNB在微粒中的释放率达到95±1.31%。这些结果为构建提高热稳定性的 LNB 传输系统提供了理论和技术途径。

更新日期：2023-03-14

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