NIR Light-Mediated Mitochondrial RNA Modification for Cancer RNA Interference Therapeutics,Angewandte Chemie International Edition

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NIR Light-Mediated Mitochondrial RNA Modification for Cancer RNA Interference Therapeutics
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-03-13 , DOI: 10.1002/anie.202218969
Yali Feng ₁ , Jing Fang ₁ , Yan Zhao ₁ , Shuyue Ye ₁ , Anna Wang ₁ , Yuqi Zhang ₁ , Jinfeng Zhu _{1,

2} , Jiachen Li ₁ , Zhengzhong Lv ₁ , Zhongsheng Zhao ₁ , Haibin Shi ₁

Affiliation

Taking advantage of the well-known cyclization reaction between furan and nucleotides of nucleic acid under the ignition of ¹O₂, a near-infrared (NIR) light-mediated mitochondrial RNA modification (NIMiRM) strategy was herein developed for long-term NIR/PA dual-modality imaging and remarkable suppression of tumors in vivo.

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