Trifluoromethyl copper (CuCF₃), as a diverse fluorination reagent, has been widely used in trifluoromethylation, perfluoroalkylation, and difluorocarbene reactions. However, it has rarely been reported as a single fluorine source involved in nucleophilic fluorination reactions. This work describes a general strategy involving copper-mediated deoxyfluorination of redox-active esters to rapidly access various aliphatic and aromatic acyl fluorides. The highly active CuF species could be generated from either copper fluoride salts or CuCF₃. A plausible mechanism of CuCF₃ forming an [F-CuCF₂F₅]- intermediate and NHBC ester forming acyl fluoride has been derived from DFT calculations.

三氟甲基铜（CuCF ₃）作为一种多样化的氟化试剂，广泛应用于三氟甲基化、全氟烷基化和二氟卡宾反应。然而，它很少被报道为参与亲核氟化反应的单一氟源。这项工作描述了一种通用策略，涉及铜介导的氧化还原活性酯的脱氧氟化，以快速获得各种脂肪族和芳香族酰基氟。高活性的 CuF 物质可以从氟化铜盐或 CuCF ₃中产生。_{CuCF 3}形成[F-CuCF ₂ F ₅ ]-中间体和NHBC酯形成酰基氟的可能机制已从DFT计算推导出来。