格氏乳杆菌 LG-G12 恢复接受头孢曲松治疗的肥胖小鼠的肠道微生物群和肠道健康。,Foods

当前位置： X-MOL 学术 › Foods › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

格氏乳杆菌 LG-G12 恢复接受头孢曲松治疗的肥胖小鼠的肠道微生物群和肠道健康。
Foods ( IF 4.7 ) Pub Date : 2023-03-03 , DOI: 10.3390/foods12051092
Mariana de Moura E Dias ₁ , Vinícius da Silva Duarte ₂ , Lúcio Flávio Macedo Mota ₃ , Gabriela de Cássia Ávila Alpino ₁ , Sandra Aparecida Dos Reis Louzano ₁ , Lisiane Lopes da Conceição ₁ , Hilário Cuquetto Mantovanie ₄ , Solange Silveira Pereira ₁ , Leandro Licursi Oliveira ₅ , Tiago Antônio de Oliveira Mendes ₆ , Davide Porcellato ₂ , Maria do Carmo Gouveia Peluzio ₁

Affiliation

肠道菌群失调与肥胖等代谢性疾病的发生有关。因此，它的调节是恢复肠道微生物群和改善肥胖者肠道健康的有前途的策略。本文探讨了益生菌、抗菌剂和饮食在调节肠道微生物群和改善肠道健康方面的作用。因此，在 C57BL/6J 小鼠中诱导肥胖，之后将它们重新分配并喂食致肥胖饮食（干预 A）或标准 AIN-93 饮食（干预 B）。同时，所有组都经历了使用格氏乳杆菌 LG-G12、头孢曲松或头孢曲松，然后使用格氏乳杆菌 LG-G12 的治疗阶段。在实验期结束时，进行了以下分析：元分类学分析、肠道菌群功能分析、肠道通透性、和短链脂肪酸的盲肠浓度。高脂肪饮食损害了细菌多样性/丰富度，这与 L. gasseri LG-G12 和 AIN-93 饮食有关。此外，产生 SCFA 的细菌与高肠道通透性参数呈负相关，这通过肠道微生物群的功能概况预测得到进一步证实。这些发现基于肠道健康的改善，无论是否接受抗菌治疗，都提出了抗肥胖益生菌的新观点。通过肠道微生物群的功能概况预测进一步证实了这一点。这些发现基于肠道健康的改善，无论是否接受抗菌治疗，都提出了抗肥胖益生菌的新观点。通过肠道微生物群的功能概况预测进一步证实了这一点。这些发现基于肠道健康的改善，无论是否接受抗菌治疗，都提出了抗肥胖益生菌的新观点。

"点击查看英文标题和摘要"

Lactobacillus gasseri LG-G12 Restores Gut Microbiota and Intestinal Health in Obesity Mice on Ceftriaxone Therapy.

Gut microbiota imbalance is associated with the occurrence of metabolic diseases such as obesity. Thus, its modulation is a promising strategy to restore gut microbiota and improve intestinal health in the obese. This paper examines the role of probiotics, antimicrobials, and diet in modulating gut microbiota and improving intestinal health. Accordingly, obesity was induced in C57BL/6J mice, after which they were redistributed and fed with an obesogenic diet (intervention A) or standard AIN-93 diet (intervention B). Concomitantly, all the groups underwent a treatment phase with Lactobacillus gasseri LG-G12, ceftriaxone, or ceftriaxone followed by L. gasseri LG-G12. At the end of the experimental period, the following analysis was conducted: metataxonomic analysis, functional profiling of gut microbiota, intestinal permeability, and caecal concentration of short-chain fatty acids. High-fat diet impaired bacterial diversity/richness, which was counteracted in association with L. gasseri LG-G12 and the AIN-93 diet. Additionally, SCFA-producing bacteria were negatively correlated with high intestinal permeability parameters, which was further confirmed via functional profile prediction of the gut microbiota. A novel perspective on anti-obesity probiotics is presented by these findings based on the improvement of intestinal health irrespective of undergoing antimicrobial therapy or not.

更新日期：2023-03-03

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文