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Halogen-free oxidation of aryl ketones and benzyl nitrile derivatives to corresponding carboxylic acids by using NaOH/ TBHP in aqueous medium
Tetrahedron ( IF 2.1 ) Pub Date : 2023-03-11 , DOI: 10.1016/j.tet.2023.133359
Arvind Kumar Jaiswal , Ajay Kishor Kushawaha , Shubham Pandey , Abhishek Kumar , Koneni V. Sashidhara

Using inexpensive NaOH as the base and aq. TBHP (70%) as the oxidant, we have developed an efficient oxidative methodology for converting aryl ketones and benzyl nitrile derivatives to their corresponding acids in good yields. Several industrially relevant carboxylic acids could be easily synthesized in gram scale using this protocol.



中文翻译:

在水性介质中使用 NaOH/TBHP 将芳基酮和苄基腈衍生物无卤氧化成相应的羧酸

使用便宜的 NaOH 作为碱和水溶液。TBHP (70%) 作为氧化剂,我们开发了一种有效的氧化方法,可将芳基酮和苄基腈衍生物以良好的收率转化为相应的酸。使用该协议可以很容易地以克规模合成几种工业相关的羧酸。

更新日期:2023-03-11
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